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• W2189077372 endingPage "461" @default.
• W2189077372 startingPage "447" @default.
• W2189077372 abstract "Lactoperoxidase (LPO) belongs to the immunologically relevant mammalian heme peroxidases. The enzyme contributes in external secretions to the humoral immune defense against pathogens by oxidation of thiocyanate (SCN(-)) and iodide (I(-)). The generation of oxidized thiocyanate and/or iodine species is also important in numerous biotechnological applications of LPO.In this review, we give an overview about the present knowledge of LPO concerning enzymatic structure, catalytic cycles and (pseudo-)halogenated species generated by the enzyme. Redox properties of LPO as well as kinetic aspects regarding the different enzymatic cycles are discussed in order to gain insights into the disturbance of the (pseudo-)halogenating enzyme activity under pathological conditions. Important structural features of LPO and crystallographic studies on the interaction and reaction of organic substrates with the enzyme are also summarized. A broad discussion is devoted to the binding and oxidation of substrates that either inhibit or promote LPO activity.On the basis of these data, different strategies to further optimize LPO functions in humoral defense of mucous surfaces and biotechnological applications are discussed. In particular, hydrophobic organic substrates with a 3,4-dihydroxyphenyl partial structure considerably enhance the (pseudo-)halogenating activity of LPO. Their application provides, thus, a new strategy to enhance the anti-microbial activity of this enzyme." @default.
• W2189077372 created "2016-06-24" @default.
• W2189077372 creator A5014765804 @default.
• W2189077372 creator A5029481281 @default.
• W2189077372 creator A5054448007 @default.
• W2189077372 creator A5088999919 @default.
• W2189077372 date "2015-11-11" @default.
• W2189077372 modified "2023-10-16" @default.
• W2189077372 title "Lactoperoxidase as a potential drug target" @default.
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