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- W2189095679 abstract "SeveraldisordershavebeenassociatedwithmutationsinNa,K-ATPaseisoforms(rapid-onsetdystoniaparkinsonism,familialhemiplegic migraine type-2), as well as reduction in Na,K-ATPase content (depression and Alzheimer’s disease), thereby raising the issue of whetherhaploinsufficiencyoralteredenzymaticfunctioncontributetodiseaseetiology.Threeisoformsareexpressedinthebrain:the1 isoformisfoundinmanycelltypes,the2isoformispredominantlyexpressedinastrocytes,andthe3isoformisexclusivelyexpressed in neurons. Here we show that mice heterozygous for the 2 isoform display increased anxiety-related behavior, reduced locomotor activity, and impaired spatial learning in the Morris water maze. Mice heterozygous for the 3 isoform displayed spatial learning and memory deficits unrelated to differences in cued learning in the Morris maze, increased locomotor activity, an increased locomotor responsetomethamphetamine,anda40%reductioninhippocampalNMDAreceptorexpression.Incontrast,heterozygous1isoform mice showed increased locomotor response to methamphetamine and increased basal and stimulated corticosterone in plasma. The learning and memory deficits observed in the 2 and 3 heterozygous mice reveal the Na,K-ATPase to be an important factor in the functioning of pathways associated with spatial learning. The neurobehavioral changes seen in heterozygous mice suggest that these mousemodelsmaybeusefulinfutureinvestigationsoftheassociatedhumanCNSdisorders." @default.
- W2189095679 created "2016-06-24" @default.
- W2189095679 creator A5029438033 @default.
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- W2189095679 date "2007-01-01" @default.
- W2189095679 modified "2023-09-27" @default.
- W2189095679 title "DeficiencyinNa,K-ATPaseIsoformGenesAltersSpatial Learning,MotorActivity,andAnxietyinMice" @default.
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