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- W2189125989 abstract "The aim of this study was to investigate the effects of cardamom essential oil and antibiotics combinations against methicillin-resistant clinical isolates and ATCC 25923 reference strain of Staphylococcus aureus. The interaction of the essential oil with the antibiotics was assessed by the checkerboard method. The chemical composition of essential oil was analysed by gas chromatography with mass spectrometry (GC-MS) and gas chromatography with flame ionization detection (GC-FID) and α-terpinyl acetate (39.59%) and 1,8-cineole (31.27%) were identified as main compounds. Combinations of cardamom essential oil with amoxicillin or ciprofloxacin exerted mainly additive and indifferent effects on methicillin-resistant clinical isolates while combinations of 1,8-cineol with antibiotics generated antagonistic and indifferent effects. Additive effects on Staphylococcus aureus ATCC 25923 were generated by the following combinations: cardamom essential oil ‐ ciprofloxacin, 1,8-cineol ‐ amoxicillin and 1,8-cineol ‐ ciprofloxacin. The antagonistic interactions noted here, particularly for 1,8-cineol, suggest that its concomitant administration with amoxicillin or ciprofloxacin, depending on the combination ratios, can diminish the antibacterial activity of these antibiotics in infections with Staphyloccocus aureus isolates. Rezumat Acest studiu a avut drept obiectiv investigarea efectelor combinațiilor intre uleiul volatil de cardamom și antibiotice asupra unor izolate clinice meticilin-rezistente și tulpinii standard ATCC 25923 a patogenului Staphylococcus aureus. Interacțiunea uleiului volatil cu antibiotice a fost evaluata prin metoda checkerboard. Compoziția chimica a uleiului volatil a fost analizata prin GC-MS și GC-FID, iar acetatul de α-terpinil (39,59%) și 1,8cineolul (31,27%) au fost identificați drept constituenţi majoritari. Combinațiile uleiului volatil de cardamom cu amoxicilina sau ciprofloxacina au exercitat, in principal, efecte aditive și indiferente asupra izolatelor clinice meticilin-rezistente de stafilococ auriu in timp ce combinațiile 1,8-cineolului cu antibiotice au generat efecte antagonice și indiferente. Urmatoarele combinații: ulei volatil de cardamom-ciprofloxacina; 1,8-cineol-amoxicilina și" @default.
- W2189125989 created "2016-06-24" @default.
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- W2189125989 date "2014-01-01" @default.
- W2189125989 modified "2023-09-24" @default.
- W2189125989 title "INTERACTIONS BETWEEN CARDAMOM ESSENTIAL OIL AND CONVENTIONAL ANTIBIOTICS AGAINST STAPHYLOCOCCUS AUREUS CLINICAL ISOLATES" @default.
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