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- W2189182175 abstract "To investigated the eff ect of high volume continuous hemofi ltration (HVHF) on the lung lesion observed with transesophageal echocardiography (TEE) in endotoxin‑induced acute lung injury in piglets. Piglets weighing 20‑30kg. Interventions: After endotoxin of 20 μg/kg intravenous administration animals were randomly assigned to control group (n=7) and HVHF group (n=7) . In both group fi ltration was performed for fi ve hours and zero balanced. Filtration fl ow was 150 ml/hr in HVHF group and 0ml/hr in control group. The area of the lesion resistive index and maximal blood velocity in regional pulmonary artery were estimated using TEE. High mobility group B1 protein (HMGB1) cortisol and catecholamine concentrations were measured in plasma at endotoxin 5 hours. Measurements of blood gas hemodynamics and TEE images were obtained every hour. The value of PaO2 density area and resistive index were 70.0±8.8 mmHg 10.7±4.5 cm 2 and 0.61±0.23 in control group and 120.4±20.3 mmHg 3.3±2.0 cm 2 and 0.88 ±0.22 in HVHF group at endotoxin 5 hours respectively (mean±SD) . PaO2 and resistive index increased and density area decreased in HVHF group than those of control group signifi cantly (p<0.05 respectively) . There was signifi cant relationship between PaO2 and density area (r=0.76 p<0.01) . There was no signifi cant diff erence in hemodynamics HMGB1 cortisol and catecholamines concentration in plasma and morphometry between control group and HVHF group. In conclusion these results suggest that non‑specifi c blood purifi cation with HVHF improves arterial oxygenation and lung image observed with TEE in endotoxin‑induced acute lung injury in piglets." @default.
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- W2189182175 date "2007-11-29" @default.
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- W2189182175 title "CONTINUOUS VENOVENOUS HEMOFILTRATION IMPROVES ENDOTOXIN INDUCED LUNG INJURY IN PIGS -EVALUATION WITH ULTRASONOGRAPHY-" @default.
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