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- W2189188245 abstract "Summary A study was undertaken to evaluate the effect of antioxidants such as β-carotene, vitamin C and vitamin E on oxidative stress and streptozotocin-induced diabetic nephropathy in rats. The rats were rendered diabetic by a single intraperitoneal injection of Streptozotocin (50 mg/kg), which was assessed by determining the blood glucose levels. Serum TBARS and plasma GSH levels were estimated to assess the oxidative stress. Furthermore, parameters like BUN, serum creatinine and urinary albumin were determined to assess the effect of antioxidants on diabetic nephropathy. Treatment with β-carotene (10 mg/kg/day i.p.), vitamin C (10 mg/kg/day i.p.) and vitamin E (40 mg/kg/day i.p.) showed significant ameliorative effects on oxidative stress and nephropathy in diabetic rats. Moreover, β-carotene was found to be more potent in the amelioration of oxidative stress and diabetic nephropathy when compared with vitamin C and vitamin E that may be due to its potent antioxidant property." @default.
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- W2189188245 date "2009-01-01" @default.
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- W2189188245 title "Beneficial Effects of Antioxidants on Oxidative Stress and Diabetes-Induced Experimental Nephropathy" @default.
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