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- W2189199310 abstract "Bovine leukemia virus (BLV) is an exogenous retrovirus and associated with enzootic bovine leukosis (EBL)4 which often includes persistent lymphocytosis and development of B-cell lymphosarcoma/leukemia after a long latent period. Natural cases of malignant lymphomas are rare in sheep. Under experimental conditions, however, sheep are easily infected with BLV7 and develop B-cell lymphosarcoma/leukemia at a higher frequency and within a shorter period (1 to 3 years) than cattle. Sheep also show serologic and pathologic responses to BLV similar to those in The lymphoid systems of sheep and cattle contain a large number of the CD4- CD8- “double-negative” T lymphocyte s~bpopulation~-~ in striking contrast to the lymphoid systems of human and mouse. These double-negative lymphocytes are known to express the y6 chains of T cell receptor (TCR)2.3 as well as a surface molecule termed T19.6 In spleen and lymph nodes, y6 T cells are localized in regions of cellular traffic5 and they exhibit cytotoxic activity against allogenic cells. In order to elucidate the role of y6 T cells in BLVinfected sheep, we examined, by flow cytometry, the population of y6 T cells in the peripheral blood mononuclear cells (PBMC). The distribution of these cells in the superficial cervical lymph nodes of BLV-infected sheep was examined by immunohistology using the monoclonal antibody (MoAb) against the y6 TCR." @default.
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- W2189199310 date "1994-01-01" @default.
- W2189199310 modified "2023-09-27" @default.
- W2189199310 title "BRIEF COMMUNICATIONS and CASE REPORTS The y6 T Cell Population in Sheep Experimentally Infected with Bovine Leukemia Virus" @default.
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