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- W2189202330 abstract "We present and discuss the steady state velocity profiles obtained by micro particle- image velocimetry (PPIV). A blood sample was sent through a flat micro capillary, and average velocity fields were measured for different, positions of t,he focal plane. We observe a so-called plug flow, and find indications of a 3 pm wide cell free bomld- ary layer in the vicinity of the channel walls. Determination of the channel wall position is diflicult for particle dense fluids such as blood, but it could be achieved by utilizing knowledge on how uncertainties increase, when t,he focal plane is moved outside the channel. The efforts to develop lab-on-a-chip devices using microfluidics have increased sub- stantially during the past few years (I). A n important sub-field in microfluidics concerns the behavior of blood flowing in microchannels~ and it has therefore be- come of high interest to obtain detailed information about the properties of such flows. In particular the nonlinear flow properties of blood are interesting. To date, the studies of blood flow in microsystems presented in the lit,erature oft,en focus on ~~le~urenlents and models of the relation between flow rates and pressure drops? without. utilizing the support of PIV (2). One exception is Sugii et al. who presented an in vivo PIV experiment of blood flow (3). However: they did not report on the influence of velocity gradients normal to the focal plane, and such an investigation is generally needed. Furthermore, the measurements were not compared to theoretical profiles. In this work we present velocity profiles of blood flows in a flat glass capil- lary with a roughly rectangular cross-se&ion of size 28 pm by 360 pm. The profiles were measured for different positions of the focal plane. Our measnrement~s indicate t,hat blood flows as a two-phase plug flow with a 3 /urn wide cell free boundary layer. 2. Theory Data were analyzed using standard PIV-analysis. Blood is a far more complex fluid than the bead suspension we studied in Ref. (4). First,ly, it, has a very low transparency: which limits the thickness of the analyzed channel. Secondly, blood exhibits nonlinear flow properties, and thirdly the diameter of a red blood cell (8 /em) is comparable to the 28 pm high channel." @default.
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- W2189202330 date "2003-01-01" @default.
- W2189202330 modified "2023-09-26" @default.
- W2189202330 title "MICRO PIV ON BLOOD FLOW IN A MICROCHANNEL" @default.
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