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• W2189203793 abstract "The “name-to-peptide” method was used to design a 7-residue peptide amide with the amino acid sequence: Tryptophan-Alanine-Leucine-Methionine-Alanine-Arginine-Threonine. Abbreviation of this sequence with the International Union of Pure and Applied Chemistry single letter symbols for amino acids yields W-A-L-M-A-R-T, or WALMART. This abbreviation corresponds to the prominent name of an American multinational retail corporation that operates chains of large discount department and warehouse stores. The WALMART amino acid sequence occurs in several natural proteins, such as the acyl CoA dehydrogenase of Pseudomonas aeruginosa. The WALMART peptide was designed to have a carboxyl-terminal amide group in order to eliminate the negative charge that would normally occur at this end of the peptide at neutral pH, thereby enhancing the net positive charge character of the peptide. The peptide is predicted to be relatively hydrophobic (57% hydrophobic amino acid residues), to have a net charge of +2 at pH 7, and to absorb UV light at 180-220 nm (peptide bond) and 280 nm (Tryptophan). Molecular modeling of the peptide as an α-helix indicated that it was capable of forming 1.5 turns of helix, contained 4-5 hydrogen bonds, and had a length [amino-terminal amino group to carboxyl-terminal amide group] of 11 A. When modeled as a β-strand, the peptide had a length of 21 A. Peptide WALMART was synthesized as an HCl salt, in order to avoid potential undesirable effects of the trifluoroacetate anion, and its purity, molecular weight, and amino acid sequence were determined by reverse phase HPLC and mass spectrometry. The peptide was found to be readily soluble in water. The peptide inhibited proliferation of human female colorectal adenocarcinoma cells (HT-29), and growth of human male and female urinary bladder carcinoma cells (5637 and TCCSUP cells, respectively). Inhibition occurred at concentrations 5-fold lower than the concentrations of dichloroacetate used to obtain the same biological effects. A preliminary test indicated that the peptide may inhibit the growth of Staphylococcus simulans." @default.
• W2189203793 created "2016-06-24" @default.
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• W2189203793 date "2015-01-01" @default.
• W2189203793 modified "2023-09-24" @default.
• W2189203793 title "The WALMART Peptide" @default.
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