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• W2189227430 abstract "Fixed-dose combination chemotherapy holds great potential for management of cancer. Thus a drug delivery system which can administer a controlled ratio of several drugs simultaneously and control the drug release at the cancer site is highly desired. In this work, a fixed-dose dual drug loaded polymer micelle is formed by the self-assembly of a single polymer–drug conjugate carrying a combination of drugs. A predetermined ratio of the two drugs can be obtained via a facile and efficient solid-phase synthesis method. MTT assay demonstrated that the polymer micelles are more effective in altering the proliferation rate of MCF-7 tumor cells due to its higher solubility than free drugs. Furthermore, the introduction of the redox-sensitive disulfide linker between the hydrophilic PEG and the hydrophobic drugs facilitates drug release in tumor cellular redox environment and thus enhances the therapeutic effectiveness dramatically." @default.
• W2189227430 created "2016-06-24" @default.
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• W2189227430 date "2014-01-01" @default.
• W2189227430 modified "2023-09-24" @default.
• W2189227430 title "Single Polymer-drug Conjugate Carrying Two Drugs for Fixed-dose Co-" @default.
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• W2189227430 hasPublicationYear "2014" @default.
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