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- W2189235680 abstract "A new HPLC method was developed for selective and s imultaneous determination of Guaifensen and Dextromethorphan HBr tablets 1200/60 mg. The chroma tographic separation was achieved on a Acquity UPLC BEH, C18,100 x 2.1 mm, 1.7um column. The mobile pha se consisted of buffer, acetonitrile and methanol d elivered at a flow rate of 0.15 ml/min and dual wavelength a t 271 nm for Guaifensin and 220 nm for Dextromethor phan with UV detector. Accuracy found by % recovery from 98.2 to 102.2 at 50 to 150% level and the linearity res ults for Guaifensen and Dextromethorphan HBr in the specifie d concentration calibration curves linear with coef ficient of variation not less than 0.99. The proposed was foun d to be specificity, linearity, and precision, Intermediate precision and accuracy, stability of analytical sol ution and robustness. The validation was performed according to the ICH guide lines." @default.
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- W2189235680 date "2012-01-01" @default.
- W2189235680 modified "2023-09-24" @default.
- W2189235680 title "Determination of Guaifensen and Dextromethorphan by UPLC" @default.
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