FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189261710> ?p ?o ?g. }

• W2189261710 endingPage "6" @default.
• W2189261710 startingPage "40" @default.
• W2189261710 abstract "We further characterized a novel type of chimeric BCR-ABL mRNA transcript detected in a patient with Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML).We used reverse-transcription polymerase chain reaction (RT-PCR) and sequence analysis of the fusion region of the amplified cDNA fragment. Western analysis was performed on total protein.Part of exon e8 of the BCR gene was joined to an intronic sequence of ABL intron Ib spliced on exon a2 of the ABL gene, giving rise to an in-frame e8-int-a2 BCR-ABL transcript. Only part of exon 8 of the BCR gene (e8) (intra-exonic break) was retained. The consequent BCR-int-ABL transcript was translated into a BCR-ABL protein of 1804 amino acid residues with a molecular mass of 197.5 kilodaltons (kDa) called p200 BCR-ABL. The 3' part of bcr exon 8 recombined within or alongside Alu elements at the additional sites. Sequence motifs similar to consensus binding sites of the lymphoid-associated TRAX and translisin proteins were present on both participating strands at 22q11 and 9q34 recombination sites, respectively. No differences in clinical or laboratory findings at diagnosis were found between this patient and CML patients with bcr-abl fusion.The presence of Alu sequences and of the translisin binding motif on both sides of the breaks in this novel translocation suggests a possible general mechanism of molecular recombination in CML patients." @default.
• W2189261710 created "2016-06-24" @default.
• W2189261710 creator A5019949455 @default.
• W2189261710 creator A5023529754 @default.
• W2189261710 creator A5033359713 @default.
• W2189261710 creator A5036642940 @default.
• W2189261710 creator A5049395252 @default.
• W2189261710 creator A5063427645 @default.
• W2189261710 creator A5067954471 @default.
• W2189261710 creator A5068769311 @default.
• W2189261710 creator A5071192590 @default.
• W2189261710 creator A5073761054 @default.
• W2189261710 date "2000-01-01" @default.
• W2189261710 modified "2023-09-23" @default.
• W2189261710 title "Alu and translisin recognition site sequences flanking translocation sites in a novel type of chimeric bcr-abl transcript suggest a possible general mechanism for bcr-abl breakpoints." @default.
• W2189261710 cites W145991340 @default.
• W2189261710 cites W154284148 @default.
• W2189261710 cites W1573399247 @default.
• W2189261710 cites W188092000 @default.
• W2189261710 cites W1966155874 @default.
• W2189261710 cites W1967110736 @default.
• W2189261710 cites W1974410673 @default.
• W2189261710 cites W1978572335 @default.
• W2189261710 cites W1989898071 @default.
• W2189261710 cites W1994704939 @default.
• W2189261710 cites W2007558376 @default.
• W2189261710 cites W2008399824 @default.
• W2189261710 cites W2020954035 @default.
• W2189261710 cites W2032601764 @default.
• W2189261710 cites W2033049603 @default.
• W2189261710 cites W2034892057 @default.
• W2189261710 cites W2055592745 @default.
• W2189261710 cites W2056555295 @default.
• W2189261710 cites W2082941376 @default.
• W2189261710 cites W2087064593 @default.
• W2189261710 cites W2106882534 @default.
• W2189261710 cites W2114992132 @default.
• W2189261710 cites W2115512131 @default.
• W2189261710 cites W2135164000 @default.
• W2189261710 cites W2150178316 @default.
• W2189261710 cites W2163108727 @default.
• W2189261710 cites W2163775178 @default.
• W2189261710 cites W2207680991 @default.
• W2189261710 cites W2295163900 @default.
• W2189261710 cites W2328755662 @default.
• W2189261710 cites W2338131047 @default.
• W2189261710 cites W2394878975 @default.
• W2189261710 cites W2407323922 @default.
• W2189261710 cites W2410341681 @default.
• W2189261710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10629590" @default.
• W2189261710 hasPublicationYear "2000" @default.
• W2189261710 type Work @default.
• W2189261710 sameAs 2189261710 @default.
• W2189261710 citedByCount "14" @default.
• W2189261710 countsByYear W21892617102013 @default.
• W2189261710 countsByYear W21892617102014 @default.
• W2189261710 countsByYear W21892617102016 @default.
• W2189261710 crossrefType "journal-article" @default.
• W2189261710 hasAuthorship W2189261710A5019949455 @default.
• W2189261710 hasAuthorship W2189261710A5023529754 @default.
• W2189261710 hasAuthorship W2189261710A5033359713 @default.
• W2189261710 hasAuthorship W2189261710A5036642940 @default.
• W2189261710 hasAuthorship W2189261710A5049395252 @default.
• W2189261710 hasAuthorship W2189261710A5063427645 @default.
• W2189261710 hasAuthorship W2189261710A5067954471 @default.
• W2189261710 hasAuthorship W2189261710A5068769311 @default.
• W2189261710 hasAuthorship W2189261710A5071192590 @default.
• W2189261710 hasAuthorship W2189261710A5073761054 @default.
• W2189261710 hasConcept C104317684 @default.
• W2189261710 hasConcept C111829193 @default.
• W2189261710 hasConcept C123894998 @default.
• W2189261710 hasConcept C125418893 @default.
• W2189261710 hasConcept C138626823 @default.
• W2189261710 hasConcept C153911025 @default.
• W2189261710 hasConcept C170493617 @default.
• W2189261710 hasConcept C2778274637 @default.
• W2189261710 hasConcept C2778904597 @default.
• W2189261710 hasConcept C36823959 @default.
• W2189261710 hasConcept C40767141 @default.
• W2189261710 hasConcept C42362537 @default.
• W2189261710 hasConcept C43907098 @default.
• W2189261710 hasConcept C54355233 @default.
• W2189261710 hasConcept C86803240 @default.
• W2189261710 hasConceptScore W2189261710C104317684 @default.
• W2189261710 hasConceptScore W2189261710C111829193 @default.
• W2189261710 hasConceptScore W2189261710C123894998 @default.
• W2189261710 hasConceptScore W2189261710C125418893 @default.
• W2189261710 hasConceptScore W2189261710C138626823 @default.
• W2189261710 hasConceptScore W2189261710C153911025 @default.
• W2189261710 hasConceptScore W2189261710C170493617 @default.
• W2189261710 hasConceptScore W2189261710C2778274637 @default.
• W2189261710 hasConceptScore W2189261710C2778904597 @default.
• W2189261710 hasConceptScore W2189261710C36823959 @default.
• W2189261710 hasConceptScore W2189261710C40767141 @default.
• W2189261710 hasConceptScore W2189261710C42362537 @default.
• W2189261710 hasConceptScore W2189261710C43907098 @default.
• W2189261710 hasConceptScore W2189261710C54355233 @default.
• W2189261710 hasConceptScore W2189261710C86803240 @default.

• next