FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189263267> ?p ?o ?g. }

• W2189263267 abstract "Six subjects with heterozygous familial hypercholesterolemia (FH) (three males, three females) formed the basis for an investigation of the pathways of production of apoprotein B within plasma low-density-lipoprotein (LDL-apoB). Following the intravenous injection of [75Se]selenomethionine as an amino acid tracer, incorporation of the radioactive isotope into the putative precursor of LDL, intermediate density lipoprotein (IDL-apoB), was examined over a 9-day period. The resulting tracer data provided the precursor profile for both the IDL catabolic conversion of LDL as well as for direct synthesis of LDL from amino acids. The fractional conversion rates, (beta) for IDL and (alpha) for amino acids to LDL-apoB, were determined utilizing the two-compartment model for LDL involving both the intravascular and the extravascular pools of apoB. This LDL model was resolved analytically and the parameters alpha and beta were determined so as to give the least squares fit to the LDL tracer data. In this solution, the fractional conversion rates of IDL and of amino acids to LDL-apoB were resolved with a mean fractional residual of 20 +/- 6%, which was randomly distributed within the LDL-apoB data throughout the 216 hours of the studies. The steady-state determination of the pathways of LDL-apoB synthesis, based upon this tracer analysis, indicate that IDL accounts for 46%, and amino acids account for 54% of total apoB production within plasma LDL in heterozygous FH. In contrast, in normal subjects, IDL accounts for 86% of total LDL-apoB production. Since the IDL catabolic pathway represents the predominant if not exclusive source of LDL in normal man, this demonstration of a major non-IDL source of LDL in FH broadens the understanding of the pathophysiology of human familial hypercholesterolemia." @default.
• W2189263267 created "2016-06-24" @default.
• W2189263267 creator A5004242956 @default.
• W2189263267 creator A5046180945 @default.
• W2189263267 creator A5046531730 @default.
• W2189263267 date "1982-07-01" @default.
• W2189263267 modified "2023-09-24" @default.
• W2189263267 title "Metabolic heterogeneity of low density lipoprotein-apoB production in familial hypercholesterolemia: an analytical model solution of tracer data." @default.
• W2189263267 cites W1548991782 @default.
• W2189263267 cites W1775749144 @default.
• W2189263267 cites W1914323296 @default.
• W2189263267 cites W1946244962 @default.
• W2189263267 cites W1964941215 @default.
• W2189263267 cites W1983853341 @default.
• W2189263267 cites W1986027615 @default.
• W2189263267 cites W1990513957 @default.
• W2189263267 cites W1994789322 @default.
• W2189263267 cites W2002700276 @default.
• W2189263267 cites W2002892589 @default.
• W2189263267 cites W2011054347 @default.
• W2189263267 cites W2011221882 @default.
• W2189263267 cites W2020946090 @default.
• W2189263267 cites W2032731208 @default.
• W2189263267 cites W2036989162 @default.
• W2189263267 cites W2085036062 @default.
• W2189263267 cites W2088681386 @default.
• W2189263267 cites W2102953109 @default.
• W2189263267 cites W2124335198 @default.
• W2189263267 cites W2135503869 @default.
• W2189263267 cites W2162462798 @default.
• W2189263267 cites W2169904273 @default.
• W2189263267 cites W2185738212 @default.
• W2189263267 cites W2335801071 @default.
• W2189263267 doi "https://doi.org/10.1016/s0022-2275(20)38107-4" @default.
• W2189263267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7119572" @default.
• W2189263267 hasPublicationYear "1982" @default.
• W2189263267 type Work @default.
• W2189263267 sameAs 2189263267 @default.
• W2189263267 citedByCount "8" @default.
• W2189263267 crossrefType "journal-article" @default.
• W2189263267 hasAuthorship W2189263267A5004242956 @default.
• W2189263267 hasAuthorship W2189263267A5046180945 @default.
• W2189263267 hasAuthorship W2189263267A5046531730 @default.
• W2189263267 hasBestOaLocation W21892632671 @default.
• W2189263267 hasConcept C121332964 @default.
• W2189263267 hasConcept C126322002 @default.
• W2189263267 hasConcept C185544564 @default.
• W2189263267 hasConcept C185592680 @default.
• W2189263267 hasConcept C2778163477 @default.
• W2189263267 hasConcept C2778863792 @default.
• W2189263267 hasConcept C2779120738 @default.
• W2189263267 hasConcept C2779620165 @default.
• W2189263267 hasConcept C2780072125 @default.
• W2189263267 hasConcept C515207424 @default.
• W2189263267 hasConcept C55493867 @default.
• W2189263267 hasConcept C62231903 @default.
• W2189263267 hasConcept C62746215 @default.
• W2189263267 hasConcept C71924100 @default.
• W2189263267 hasConcept C96942376 @default.
• W2189263267 hasConceptScore W2189263267C121332964 @default.
• W2189263267 hasConceptScore W2189263267C126322002 @default.
• W2189263267 hasConceptScore W2189263267C185544564 @default.
• W2189263267 hasConceptScore W2189263267C185592680 @default.
• W2189263267 hasConceptScore W2189263267C2778163477 @default.
• W2189263267 hasConceptScore W2189263267C2778863792 @default.
• W2189263267 hasConceptScore W2189263267C2779120738 @default.
• W2189263267 hasConceptScore W2189263267C2779620165 @default.
• W2189263267 hasConceptScore W2189263267C2780072125 @default.
• W2189263267 hasConceptScore W2189263267C515207424 @default.
• W2189263267 hasConceptScore W2189263267C55493867 @default.
• W2189263267 hasConceptScore W2189263267C62231903 @default.
• W2189263267 hasConceptScore W2189263267C62746215 @default.
• W2189263267 hasConceptScore W2189263267C71924100 @default.
• W2189263267 hasConceptScore W2189263267C96942376 @default.
• W2189263267 hasLocation W21892632671 @default.
• W2189263267 hasOpenAccess W2189263267 @default.
• W2189263267 hasPrimaryLocation W21892632671 @default.
• W2189263267 hasRelatedWork W1878443806 @default.
• W2189263267 hasRelatedWork W1883383114 @default.
• W2189263267 hasRelatedWork W1946244962 @default.
• W2189263267 hasRelatedWork W2000187193 @default.
• W2189263267 hasRelatedWork W2001539608 @default.
• W2189263267 hasRelatedWork W2011391855 @default.
• W2189263267 hasRelatedWork W2023069842 @default.
• W2189263267 hasRelatedWork W2023963452 @default.
• W2189263267 hasRelatedWork W2087532740 @default.
• W2189263267 hasRelatedWork W2088681386 @default.
• W2189263267 hasRelatedWork W2133499309 @default.
• W2189263267 hasRelatedWork W2170135723 @default.
• W2189263267 hasRelatedWork W2183983473 @default.
• W2189263267 hasRelatedWork W2188634004 @default.
• W2189263267 hasRelatedWork W2276181100 @default.
• W2189263267 hasRelatedWork W2308991364 @default.
• W2189263267 hasRelatedWork W2338330876 @default.
• W2189263267 hasRelatedWork W2345918830 @default.
• W2189263267 hasRelatedWork W2410267409 @default.
• W2189263267 hasRelatedWork W2109622343 @default.
• W2189263267 isParatext "false" @default.
• W2189263267 isRetracted "false" @default.
• W2189263267 magId "2189263267" @default.

• next