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• W2189285172 abstract "2 Abstract: Fenugreek has been used in folk medicine to treat many disorders and posses a phytoestrogenic properties which appear to have both estrogenic and anti-estrogenic effects. The study aimed to investigate the pharmacological effects of fenugreek on reproductive activity of virgin rabbits. Alcoholic extract of the fenugreek seeds (Trigonellafoenumgraecum) was prepared and Dissolved in tween 80 and dist.water to obtain 20% suspension for use. Biological assays screening were done for detection of estrogen-like activity of the extract in immature female mice. In vivo study was carried out on virgin rabbits.Thirty immature rabbits (1-1.2 kg b. wt.) were divided into three groups (10 rabbits/group). The first group was given 0.1 ml/ kg. b.wt. olive oil subcutaneously daily for 30 days (a control group). The second group (standard group) was given 0.4 µg / kg. b.wt. oestradiolmonobenzoate daily by s/c administration for 30 days. The third group was given 800mg/kg. b.wt. fenugreek ethanol extract orally for the same period. The blood samples were used for determination of hemogram and serum samples for hormonal assay. The animals were slaughtered at 30 days th of experiment and the ovaries and uteri were dissected out and weighed. The oocytes were collected from the ovarian follicles and cultured in vitro for maturation in TCM-199.The oocytes were cultured in maturation medium for 24 hrs under conditioned environment (95% relative humidity, 5% CO at 38°C). Phytochemical 2 screening of active constituents of fenugreek ethanol extract contain carbohydrates and / or glycosides, flavonoids, tannins, steroids and / or triterpenoids, alkaloids, resins and saponins. All the tested extracts produced significant oestrogen-like activities with various degrees according to the given dose (p< 0.05, 5mg/10g b.wt. and p< 0.01, 10mg/10g b.wt.) in rats. In rabbits, fenugreek(800mg/kg.b.wt.)produced significant oestrogen-like activities (p<0.001)increased significantly both uterine and ovarian weights as compared to the control group. In immature rabbitsgiven fenugreek seed extracts, the percentages of large follicular oocytes were 20%, 51% and 50% for olive oil, oestradiolmonobenzoate and fenugreek extract, respectively. Also, improved the quality of oocytes (78% vs. 65%). The maturation rate of rabbit oocytes in vitro elevated greatly in the group given oestradiolmonobenzoate (82%); or fenugreek extract (80%). In addition, the fertilization rates were increased to 45% and 44% in groups given oestradiolmonobenzoate and fenugreek ethanol extracts, respectively, as compared to the control group given olive oil (25%)." @default.
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• W2189285172 date "2014-01-01" @default.
• W2189285172 modified "2023-09-27" @default.
• W2189285172 title "Pharmacological Activity of Trigonellafoenum-graecum Seed Extract on Reproduction of Virgin Rabbits" @default.
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