Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189319794> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2189319794 abstract "With the objective of decreasing analysis time and retaining good efficiency (UPLCMS/MS) is an outstanding analytical approach for speedy biomedical analysis. The aim of this study was to develop and validate a simple, rapid, sensitive and specific UPLCMS/MS method for quantification of CZT in human plasma. After a simple protein precipitation using acetonitrile and methanol, CZT and paroxetine (IS) were separated on Acquity UPLC BEH TM C18 column (50 2.1 mm i.d., 1.7 µm, Waters, USA) using a mobile phase composed of methanol:0.1%(v/v) ammonium hydroxide (80:20) pumped at a flow rate of 0.4 mL min -1 . CZT and IS were eluted at 0.46 and 0.66 min, respectively. The mass spectrometric determination was carried out using an electrospray interface operated in the positive mode with multiple reaction monitoring mode. The mass transitions m/z 450.0 → 260.0 and m/z 330.11 → 192.11 were used to measure CZT and internal standard, respectively. Mass transition m/z 450.0 → 176.99 was used as qualifying ion for CZT. The method was linear in the concentration range of 5–500 ng mL -1 with correlation coefficient of 0.997 and lower limit of quantitation of 5 ng mL -1 . This study represents the first report describing the determination of CZT in human plasma by UPLC-MS/MS method. The proposed method is superior to the previously reported LC-MS methods in terms of the sensitivity and simplicity as the method described herein is based on simple one step protein precipitation for sample preparation and isocratic flow of mobile phase. The run time was only 2 min which is suitable for high-throughput analysis. (Received February 12, 2014; Accepted May 16, 2014)" @default.
- W2189319794 created "2016-06-24" @default.
- W2189319794 creator A5021476853 @default.
- W2189319794 creator A5032882613 @default.
- W2189319794 creator A5052817318 @default.
- W2189319794 creator A5061145294 @default.
- W2189319794 creator A5066893088 @default.
- W2189319794 creator A5075490553 @default.
- W2189319794 date "2014-01-01" @default.
- W2189319794 modified "2023-09-26" @default.
- W2189319794 title "DEVELOPMENT AND VALIDATION OF SENSITIVE UPLC-MS/MS BASED METHOD FOR THE ESTIMATION OF CRIZOTINIB IN HUMAN PLASMA" @default.
- W2189319794 cites W49021375 @default.
- W2189319794 hasPublicationYear "2014" @default.
- W2189319794 type Work @default.
- W2189319794 sameAs 2189319794 @default.
- W2189319794 citedByCount "0" @default.
- W2189319794 crossrefType "journal-article" @default.
- W2189319794 hasAuthorship W2189319794A5021476853 @default.
- W2189319794 hasAuthorship W2189319794A5032882613 @default.
- W2189319794 hasAuthorship W2189319794A5052817318 @default.
- W2189319794 hasAuthorship W2189319794A5061145294 @default.
- W2189319794 hasAuthorship W2189319794A5066893088 @default.
- W2189319794 hasAuthorship W2189319794A5075490553 @default.
- W2189319794 hasConcept C105795698 @default.
- W2189319794 hasConcept C113196181 @default.
- W2189319794 hasConcept C119128265 @default.
- W2189319794 hasConcept C162356407 @default.
- W2189319794 hasConcept C179998833 @default.
- W2189319794 hasConcept C185592680 @default.
- W2189319794 hasConcept C2780092901 @default.
- W2189319794 hasConcept C2780239050 @default.
- W2189319794 hasConcept C31827203 @default.
- W2189319794 hasConcept C33923547 @default.
- W2189319794 hasConcept C43617362 @default.
- W2189319794 hasConcept C71043704 @default.
- W2189319794 hasConcept C74774607 @default.
- W2189319794 hasConceptScore W2189319794C105795698 @default.
- W2189319794 hasConceptScore W2189319794C113196181 @default.
- W2189319794 hasConceptScore W2189319794C119128265 @default.
- W2189319794 hasConceptScore W2189319794C162356407 @default.
- W2189319794 hasConceptScore W2189319794C179998833 @default.
- W2189319794 hasConceptScore W2189319794C185592680 @default.
- W2189319794 hasConceptScore W2189319794C2780092901 @default.
- W2189319794 hasConceptScore W2189319794C2780239050 @default.
- W2189319794 hasConceptScore W2189319794C31827203 @default.
- W2189319794 hasConceptScore W2189319794C33923547 @default.
- W2189319794 hasConceptScore W2189319794C43617362 @default.
- W2189319794 hasConceptScore W2189319794C71043704 @default.
- W2189319794 hasConceptScore W2189319794C74774607 @default.
- W2189319794 hasLocation W21893197941 @default.
- W2189319794 hasOpenAccess W2189319794 @default.
- W2189319794 hasPrimaryLocation W21893197941 @default.
- W2189319794 hasRelatedWork W1823615715 @default.
- W2189319794 hasRelatedWork W1886650185 @default.
- W2189319794 hasRelatedWork W1987493686 @default.
- W2189319794 hasRelatedWork W2024409696 @default.
- W2189319794 hasRelatedWork W2031641862 @default.
- W2189319794 hasRelatedWork W2052003830 @default.
- W2189319794 hasRelatedWork W2062972523 @default.
- W2189319794 hasRelatedWork W2094783222 @default.
- W2189319794 hasRelatedWork W2330454676 @default.
- W2189319794 hasRelatedWork W2409432361 @default.
- W2189319794 hasRelatedWork W2593639073 @default.
- W2189319794 hasRelatedWork W2729554923 @default.
- W2189319794 hasRelatedWork W2766938749 @default.
- W2189319794 hasRelatedWork W2781968002 @default.
- W2189319794 hasRelatedWork W2793592117 @default.
- W2189319794 hasRelatedWork W2932733059 @default.
- W2189319794 hasRelatedWork W2963374611 @default.
- W2189319794 hasRelatedWork W2995193289 @default.
- W2189319794 hasRelatedWork W3045202750 @default.
- W2189319794 hasRelatedWork W2957206409 @default.
- W2189319794 isParatext "false" @default.
- W2189319794 isRetracted "false" @default.
- W2189319794 magId "2189319794" @default.
- W2189319794 workType "article" @default.