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- W2189337487 abstract "This study examinestwo associatedtumor markers in malig nant melanoma,sialic acid and sialyltransferase(EC 2.4.99.1). Both markers were measuredin the samesera from 66 malig nant melanomapatients, 20 rheumatoid arthritis patients, and age-andsex-matched normalcontrols.Boundsialicacidwas measuredby the thiobarbituric acid method,and sialyltransfer ase activity was measured by cytidine 5'-monophosphate-N[4-' 4C]acetylneuraminicacid incorporation in desialatedfetuin. Serumvalues for both markerswere higher amongrheumatoid arthritis patients than among controls (p = < 0.0001). Mela noma patients were divided into three groups: Group I, 34 patients with no evidence of disease at the time of sampling; Group II, 13 patients with minimaltumor burden; and Group Ill, 19 patients with advanced metastatic disease. For sialic acid, there were significant differences between all group compari sons except the normals versus Group I. By contrast, for sialyltransferase only sera from Group Ill patients showed significant increased activity. Using the calculated upper limit of normal of 2.37 @smol/ml for sialic acid and 18.1 nmol/ml/hr for sialyltransferase, 2 (6%) Group I, 4 (31%) Group II, and 18 (95%) Group Ill patients had sialic acid elevations, while cor responding results for sialyltransferasewere 0, 0, and 4(42%). There was a direct relationship between sialic acid and sialyl transferase, especially for melanomapatients with established disease( p = 0.00002). Of 24 patients with objective evidence of changing tumor burden 19 (79%) showed corresponding alterations in sialic acid concentration, while 14 (58%) showed such changes in sialyltransferase. Sialic acid was directly related to recurrence rate in Group I patients, while sialyltrans ferase was not. When used as monitors of tumor burden either to detect recurrent disease or to follow response to treatment, tumor markers need not be tumor specific. In our hands, sialic acid levels more closely reflect tumor burden than does sialyl transferase activity." @default.
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- W2189337487 date "1979-01-01" @default.
- W2189337487 modified "2023-09-27" @default.
- W2189337487 title "SerumSialicAcidand Sialyltransferase as Monitorsof TumorBurdenin MalignantMelanomaPatient" @default.
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