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• W2189342658 abstract "Selma Maria Michelin MatheusDE SOUZA, P. A. T.; MARQUES, M. J.; LIMA, C. A. H. & MATHEUS, S. M. M. Effect of Citrus aurantium l. essential oil onmuscle regeneration in mdx mice. Int. J. Morphol., 29(4):1357-1363, 2011.SUMMARY: Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by the progressiveloss of muscular strength. Mdx mutant mice show a marked deficiency in dystrophin, which was related to muscle membrane stabili ty.The aim of this study was to verify the possible protective anti-inflammatory effect of citrus oil on mdx muscle fibers. Thus, adult maleand female mdx mice (014/06-CEEA) were divided into control and citrus-treated. After 60 days of treatment, one ml of blood wascollected for creatine kinase (CK) test. Diaphragm, sternomastoideus, anterior tibial and gastrocnemius muscles were removed andprocessed according to histological routine methods. The observed alterations indicate a direct effect of citrus. Recent studies haveimproved the diagnosis of muscular diseases but with no definitions of efficient treatments. Intervention with several therapie s is importantto many patients presenting muscular dystrophy, which enables them to live longer and be more active, while there is no develop ment ofgene therapies.KEY WORDS: Muscle fiber; Duchenne muscular dystrophy; Citrus aurantium L.; mdx mouse, Muscle regeneration;Central nuclei; Creatine kinase." @default.
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• W2189342658 date "2011-01-01" @default.
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• W2189342658 title "Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice Efecto del Aceite Esencial de Citrus aurantium L. en la Regeneración Muscular en Ratones Mdx" @default.
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