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- W2189349214 abstract "Objectives: This study investigated the effects of infliximab, a monoclonal antibody against TNFα, on myocardial deforma- tion and aortic elasticity in patients with rheumatoid arthritis (RA), and the association of aortic elasticity with myocardial deformation. Study design: 38 female rheumatoid arthritis (RA) patients and 30 healthy controls were included in the study. Twenty patients received infliximab and 18 patients received prednisolone. Left ventricular (LV) longitudinal, circumferential and radial strain, systolic strain rate and early diastolic strain rate using speckle- tracking echocardiography, and aortic elasticity using M-mode echocardiography were assessed at baseline and post-treatment. Results: LV systolic longitudinal basal-, mid-, and apical strain, systolic mid- and apical strain rate, basal-, mid- and apical early strain rate, circumferential systolic apical strain and systolic strain rate were reduced in RA patients compared to controls. Compared to baseline, infliximab treatment increased aortic strain, aortic distensibility and decreased aortic β index. No significant aortic elastic changes were observed with predniso - lone treatment. Longitudinal basal- and apical strain, basal-, mid- and apical systolic and diastolic strain rates, circumferen- tial basal systolic strain, radial mid- and apical strain and apical strain rate were increased following infliximab treatment. Inflix - imab treatment improves aortic elasticity in parallel to myocar- dial deformation, but no significant association was observed following prednisolone treatment. Conclusion: Myocardial deformation is impaired in RA patients and is related to aortic stiffness. Chronic inhibition of TNFα improves LV deformation in association with aortic elasticity. ABSTRACT OZET" @default.
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- W2189349214 date "2015-01-01" @default.
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- W2189349214 title "Chronic inhibition of tumor necrosis factor-α with infliximab improves myocardial deformation in parallel with aortic elasticity in rheumatoid arthritis Romatoid artritli hastalarda tümör nekroz faktör-α'nin infliksimab ile uzun süreli inhibisyonu miyokart deformasyonunu ve buna paralel olarak aort esnekliğini düzeltir" @default.
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