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- W2189368353 abstract "Attempts to identify and describe neuroanatomical and neurochemical substrates of central reward or reinforcement mechanisms have been the subject of a large and expanding literature during the past 20 years. The approach most often used in this endeavor has utilized the intracranial self-stimulation (ICS) paradigm first described by Olds & Milner (l). whereby an�animal will perform an operant response in order to obtain electrical stimulation of the brain via a chronically implanted electrode. The predominant theory that has emerged from this body of work is the catechola mine (CA) hypothesis, first proposed by Stein (2. 3) and later elaborated upon by Crow (4). According to this hypothesis and stated in its simplest terms. central CA-containing neurons mediate the reinforcing properties of ICS. There are several excellent reviews that summarize much of the evidence supporting this theory (3-5); therefore no attempt is made to do so again. Rather the purpose of this review is to examine critically some of the data and arguments upon which the theory rests and to discuss recent experimental results that appear to be incompatible with the CA theories, at least as originally proposed." @default.
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- W2189368353 date "1978-01-01" @default.
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- W2189368353 title "MECHANISMS: A CRITICAL REVIEW OF THE CATECHOLAMINE THEORY" @default.
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