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- W2189375897 abstract "Osteonecrosis of the jaws has recently been identified as a complication in patients treated with bisphosphonates. We report two case-reports of patients with multiple myeloma treated with zoledronic acid who had developed osteonecrosis of the mandible. The duration of treatment with zoledronic acid was 13 months in each case, with a cumulative zoledronic acid dose of 72 mg in one case and 144 mg in the other. The lesions were resistant to conservative debridement, surgery and antibiotic therapy. Clinicians should be aware of this potential serious complication i.e. bone necrosis in multiple myeloma patients receiving long-term treatment with potent bisphosphonates. It is recommended to perform dental examination to identify and treat all predisposing conditions before bisphosphonate treatment is started." @default.
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- W2189375897 date "2006-01-01" @default.
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- W2189375897 title "Osteonecrosis of the jaws associated with the use of zoledronic acid in multiple myeloma patients" @default.
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