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• W2189446050 abstract "The current research in the field of drug delivery by which pulsatile release can be achieved has been intensified. The present study was an attempt to develop and evaluate an oral pulsatile drug delivery system using Luffa aegyptica mill powder as a novel superdisintegrant. The basic design of the device consisted of a rapid release tabletted core and a controlled release coat. The rapid release tableted core contained a model drug (Diclofenac sodium) and novel superdisintegrant (Luffa aegyptica mill) and controlled release effect was achieved with a combination of coating material (Polyvinylpyrrolidone K30 and Hydroxypropyl methyl cellulose K4M. A 3 2 full factorial design was employed for the optimization of developed formulation considering concentration of superdisintegrant and coating ratio as independent variables with lag time and drug release as dependent variables. The developed formulations showed uniform appearance, average weight, drug content and adequate hardness. The increase in lag time was observed with an increase in HPMC concentration and decreased concentration of novel Superdisintegrant. Design expert software ® was used to give the solution for optimized formulation based on the evaluation of the developed formulations. Further comparison of Luffa aegyptica mill powder in concentration suggested in the optimized formulation with pharmaceutically acceptable superdisintegrant in same concentration showed almost similar drug release behavior. It can be concluded from the outcome of the present research that Luffa aegyptica mill powder, a natural superdisintegrant, can prove to be best alternative to the existing semisynthetic or synthetic superdisintegrants." @default.
• W2189446050 created "2016-06-24" @default.
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• W2189446050 date "2013-01-01" @default.
• W2189446050 modified "2023-09-27" @default.
• W2189446050 title "Evaluation of Novel Superdisintegrant for the Development of Pulsatile Drug Delivery System" @default.
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