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- W2189448523 abstract "1Likewise, interventions reducing intracellular triglyceride content improve insulin sensitivity. These data suggest that the connection between HCV and insulin resistance may be secondary to the ability of HCV to induce hepatic steatosis. Defects in insulin receptor and insulin-receptor substrates (IRS-1) are associated with insulin resistance and type 2 diabetes. Another possible explanation for insulin resistance in HCV is a direct effect of HCV proteins on insulin signaling pathways. Insulin action is mediated by binding to the cell surface insulin receptor which undergoes autophosphorylation with activation of kinase activity. 2 The signal is transmitted by subsequent tyrosine phosphorylation of a family of insulin-receptor substrates (IRS). In a transgenic mouse model that specifically expresses the HCV core protein at high levels in hepatocytes it was shown that hepatic insulin resistance can be induced solely by expression of the HCV core protein, and that signaling abnormalities in the insulin receptor (IRS 1) pathways are present before the development of steatosis." @default.
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- W2189448523 date "2008-01-01" @default.
- W2189448523 modified "2023-09-24" @default.
- W2189448523 title "Xw|àÉÜ|tÄ Chronic hepatitis C and diabetes mellitus - Are they related?" @default.
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