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- W2189449849 abstract "The present research work discusses the development of a UV spectrophotometric method for Voriconazole. Simple, accurate and cost efficient s pectrophotometric method has been developed for the estimation of Voriconazole in bulk and tablet dosage form. The optimum conditions for the analysis of the drug we re established. The maximum wavelength ( λ max) was found to be 255nm. The percentage recovery of Voriconazole was in the 99.61-101.63%. Beers law was obeyed in the concentration range of 5-35 �g/ml. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y=0.024x-0.000 with correlation coefficient of 0.9999 was obtained. Val idation was performed as ICH guidelines for Specifi city, linearity, accuracy, precision, INTRODUCTION: Voriconazole (2R, 3S)-2-(2,4-diflurophenyl)-3-(5-fl uoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol- 1-yl)-2-butanol isa triazole anti-fungal agent. The primary mode of action of voriconazole is the inhi bition of fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol bi osynthesis. The accumulation of 14 alpha-methyl sterols correla tes with the subsequent loss of ergosterol in the f ungal cell wall and may be responsible for the antifungal activity of voriconazole. Voriconazole has been shown to be more selective for fungal cytochrome P-450 enzymes than for various mammalian cytochrome P-450 enzyme systems." @default.
- W2189449849 created "2016-06-24" @default.
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- W2189449849 date "2011-01-01" @default.
- W2189449849 modified "2023-09-27" @default.
- W2189449849 title "DEVELOPMENT AND VALIDATION OF NEW ANALYTICAL METHOD FOR VORICONAZOLE BY USING UV-SPECTROPHOTOMETER" @default.
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