FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189465456> ?p ?o ?g. }

• W2189465456 endingPage "503" @default.
• W2189465456 startingPage "495" @default.
• W2189465456 abstract "Abstract Retinoblastoma is initiated by loss of both RB1 alleles. Previous studies have shown that retinoblastoma tumors also show further genomic gains and losses. We now define a 2.62 Mbp minimal region of genomic loss of chromosome 16q22, which is likely to contain tumor suppressor gene(s), in 76 retinoblastoma tumors, using loss of heterozygosity (30 of 76 tumors) and quantitative multiplex PCR (71 of 76 tumors). The sequence-tagged site WI-5835 within intron 2 of the cadherin-11 (CDH11) gene showed the highest frequency of loss (54%, 22 of 41 samples tested). A second hotspot for loss (39%, 9 of 23 samples tested) was detected within intron 2 of the cadherin-13 (CDH13) gene. Furthermore, deletion of the exons of CDH11 and/or WI-5835 was shown by quantitative multiplex PCR in 17 of 30 (57%) of previously untested tumors. Immunoblot analyses revealed that 91% (20 of 22) retinoblastoma exhibited either a complete loss or a decrease of the intact form of CDH11 and 8 of 13 showed a prevalent band suggestive of the variant form. Copy number of WI-5835 for these samples correlated with CDH11 protein expression. CDH11 staining was evident in the inner nuclear layer in early mouse retinal development and in small transgenic murine SV40 large T antigen–induced retinoblastoma tumors, but advanced tumors frequently showed loss of CDH11 expression by reverse transcription-PCR, suggestive of a role for CDH11 in tumor progression or metastasis. CDH13 protein and mRNA were consistently expressed in all human and murine retinoblastoma compared with normal adult human retina. Our analyses implicate CDH11, but not CDH13, as a potential tumor suppressor gene in retinoblastoma." @default.
• W2189465456 created "2016-06-24" @default.
• W2189465456 creator A5005073779 @default.
• W2189465456 creator A5016379741 @default.
• W2189465456 creator A5021107104 @default.
• W2189465456 creator A5027852339 @default.
• W2189465456 creator A5030506018 @default.
• W2189465456 creator A5066055721 @default.
• W2189465456 creator A5076162788 @default.
• W2189465456 creator A5080298585 @default.
• W2189465456 date "2004-09-01" @default.
• W2189465456 modified "2023-10-18" @default.
• W2189465456 title "Minimal 16q Genomic Loss Implicates <i>Cadherin-11</i> in Retinoblastoma" @default.
• W2189465456 cites W1609474046 @default.
• W2189465456 cites W1651458958 @default.
• W2189465456 cites W1967751087 @default.
• W2189465456 cites W1968046362 @default.
• W2189465456 cites W1973757037 @default.
• W2189465456 cites W1974670959 @default.
• W2189465456 cites W1983982755 @default.
• W2189465456 cites W1988567128 @default.
• W2189465456 cites W1989082845 @default.
• W2189465456 cites W1992450235 @default.
• W2189465456 cites W2012087000 @default.
• W2189465456 cites W2021118284 @default.
• W2189465456 cites W2026262319 @default.
• W2189465456 cites W2035916850 @default.
• W2189465456 cites W2039822420 @default.
• W2189465456 cites W2041597883 @default.
• W2189465456 cites W2048303068 @default.
• W2189465456 cites W2055363456 @default.
• W2189465456 cites W2061713879 @default.
• W2189465456 cites W2063367127 @default.
• W2189465456 cites W2073278946 @default.
• W2189465456 cites W2078510111 @default.
• W2189465456 cites W2081367622 @default.
• W2189465456 cites W2087625745 @default.
• W2189465456 cites W2102411854 @default.
• W2189465456 cites W2116395410 @default.
• W2189465456 cites W2127946085 @default.
• W2189465456 cites W2137717201 @default.
• W2189465456 cites W2141596803 @default.
• W2189465456 cites W2157449826 @default.
• W2189465456 cites W4251768308 @default.
• W2189465456 doi "https://doi.org/10.1158/1541-7786.495.2.9" @default.
• W2189465456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15383628" @default.
• W2189465456 hasPublicationYear "2004" @default.
• W2189465456 type Work @default.
• W2189465456 sameAs 2189465456 @default.
• W2189465456 citedByCount "60" @default.
• W2189465456 countsByYear W21894654562012 @default.
• W2189465456 countsByYear W21894654562013 @default.
• W2189465456 countsByYear W21894654562014 @default.
• W2189465456 countsByYear W21894654562015 @default.
• W2189465456 countsByYear W21894654562016 @default.
• W2189465456 countsByYear W21894654562017 @default.
• W2189465456 countsByYear W21894654562018 @default.
• W2189465456 countsByYear W21894654562019 @default.
• W2189465456 countsByYear W21894654562020 @default.
• W2189465456 countsByYear W21894654562021 @default.
• W2189465456 countsByYear W21894654562022 @default.
• W2189465456 countsByYear W21894654562023 @default.
• W2189465456 crossrefType "journal-article" @default.
• W2189465456 hasAuthorship W2189465456A5005073779 @default.
• W2189465456 hasAuthorship W2189465456A5016379741 @default.
• W2189465456 hasAuthorship W2189465456A5021107104 @default.
• W2189465456 hasAuthorship W2189465456A5027852339 @default.
• W2189465456 hasAuthorship W2189465456A5030506018 @default.
• W2189465456 hasAuthorship W2189465456A5066055721 @default.
• W2189465456 hasAuthorship W2189465456A5076162788 @default.
• W2189465456 hasAuthorship W2189465456A5080298585 @default.
• W2189465456 hasBestOaLocation W21894654561 @default.
• W2189465456 hasConcept C104317684 @default.
• W2189465456 hasConcept C143589142 @default.
• W2189465456 hasConcept C153911025 @default.
• W2189465456 hasConcept C180754005 @default.
• W2189465456 hasConcept C2776577112 @default.
• W2189465456 hasConcept C2778264664 @default.
• W2189465456 hasConcept C36823959 @default.
• W2189465456 hasConcept C502942594 @default.
• W2189465456 hasConcept C54355233 @default.
• W2189465456 hasConcept C555283112 @default.
• W2189465456 hasConcept C86803240 @default.
• W2189465456 hasConcept C94671646 @default.
• W2189465456 hasConceptScore W2189465456C104317684 @default.
• W2189465456 hasConceptScore W2189465456C143589142 @default.
• W2189465456 hasConceptScore W2189465456C153911025 @default.
• W2189465456 hasConceptScore W2189465456C180754005 @default.
• W2189465456 hasConceptScore W2189465456C2776577112 @default.
• W2189465456 hasConceptScore W2189465456C2778264664 @default.
• W2189465456 hasConceptScore W2189465456C36823959 @default.
• W2189465456 hasConceptScore W2189465456C502942594 @default.
• W2189465456 hasConceptScore W2189465456C54355233 @default.
• W2189465456 hasConceptScore W2189465456C555283112 @default.
• W2189465456 hasConceptScore W2189465456C86803240 @default.
• W2189465456 hasConceptScore W2189465456C94671646 @default.
• W2189465456 hasIssue "9" @default.
• W2189465456 hasLocation W21894654561 @default.

• next