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- W2189490328 abstract "Th e antiphospholipid syndrome (APS) was fi rst described in 1986. Th e original association of this hypercoagulable state with anticardiolipin antibodies (aCL) resulted from the synthesis of evidence stemming from laboratory fi ndings in systemic erythematosus (SLE), ie, the frequent occurrence of false-positive VDRL tests and the paradoxical observation of the so-called lupus anticoagulant (LA), an increase in phospholipid (PL)-dependent clotting times. By the early 1990s, it was clear that a co-factor was involved in the reaction of antibodies to PL (aPL) in SLE patients with secondary APS and that this was a hitherto-obscure protein, beta-2 glycoprotein I (β2GPI). In the intervening years, it has been established that β2GPI and other PL-binding proteins such as prothrombin (PT) are relevant antigens in APS and assays for these antigens have been developed, standardized, and applied to subjects with both primary and secondary APS. Measurement and confi rmation of LA activity is based on a stepwise approach and should follow the recommendations of the International Society of Th rombosis and Haemostasis. Although antibodies to various PL-binding proteins have been suggested as diagnostic targets for APS, the current (2006) consensus guidelines recognize only LA, aCL, and anti-β2GPI for the classifi cation of APS." @default.
- W2189490328 created "2016-06-24" @default.
- W2189490328 creator A5023501704 @default.
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- W2189490328 date "2007-01-01" @default.
- W2189490328 modified "2023-09-26" @default.
- W2189490328 title "Review: Laboratory Evaluation of the Antiphospholipid Syndrome" @default.
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- W2189490328 cites W1495740329 @default.
- W2189490328 cites W1499412752 @default.
- W2189490328 cites W1507631870 @default.
- W2189490328 cites W158721957 @default.
- W2189490328 cites W1596313173 @default.
- W2189490328 cites W164294543 @default.
- W2189490328 cites W168978929 @default.
- W2189490328 cites W1711041951 @default.
- W2189490328 cites W1749020972 @default.
- W2189490328 cites W1840660994 @default.
- W2189490328 cites W1888200383 @default.
- W2189490328 cites W1895443625 @default.
- W2189490328 cites W1927965016 @default.
- W2189490328 cites W1953041691 @default.
- W2189490328 cites W1963752281 @default.
- W2189490328 cites W1964724987 @default.
- W2189490328 cites W1973782940 @default.
- W2189490328 cites W1975751800 @default.
- W2189490328 cites W1977615320 @default.
- W2189490328 cites W1980925348 @default.
- W2189490328 cites W1992161307 @default.
- W2189490328 cites W1994384381 @default.
- W2189490328 cites W2000383134 @default.
- W2189490328 cites W2005804010 @default.
- W2189490328 cites W2009197830 @default.
- W2189490328 cites W2015087684 @default.
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- W2189490328 cites W2020307693 @default.
- W2189490328 cites W2021306080 @default.
- W2189490328 cites W2032716241 @default.
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- W2189490328 cites W2035425054 @default.
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- W2189490328 cites W2046308965 @default.
- W2189490328 cites W2053108260 @default.
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- W2189490328 cites W2067313065 @default.
- W2189490328 cites W2074956393 @default.
- W2189490328 cites W2079878945 @default.
- W2189490328 cites W2080250830 @default.
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- W2189490328 cites W2098386810 @default.
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- W2189490328 cites W2295271763 @default.
- W2189490328 cites W2316637300 @default.
- W2189490328 cites W2317626911 @default.
- W2189490328 cites W2332313529 @default.
- W2189490328 cites W2397247851 @default.
- W2189490328 cites W2397505128 @default.
- W2189490328 cites W2398112451 @default.
- W2189490328 cites W2399566282 @default.
- W2189490328 cites W2411060503 @default.
- W2189490328 cites W2413103043 @default.
- W2189490328 cites W2415371444 @default.
- W2189490328 cites W2416822367 @default.
- W2189490328 cites W2417920681 @default.
- W2189490328 cites W2466949744 @default.
- W2189490328 cites W2469620425 @default.
- W2189490328 cites W2470469344 @default.
- W2189490328 cites W3119604573 @default.
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- W2189490328 cites W46715830 @default.
- W2189490328 cites W6001644 @default.
- W2189490328 cites W6119856 @default.
- W2189490328 cites W93524816 @default.
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