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- W2189492707 abstract "Pharmacological analysis is one of the major tools in physiology. Therefore, it is important to be aware of non-specific effects of receptor agonists/antagonists. Beside other questions, pharmacological analysis is widely used to study a question of corelease of different neurotransmitters. Because concentration of transmitter in synaptic cleft is rather high, and only competitive antagonists are often available, high concentration of the antagonists are required to block the receptor of interest, making question of specificity even more important. Considering important earlier observation (Nakazawa et al., 1995) regarding suppressing side-effect of broad spectrum antagonist of P2X-receptors suramin on currents evoked by exogenous GABA application (GABA-currents), we studied effects of two other antagonists NF279 (8,8'[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)] bis-1,3,5naphthalenetrisulfonic acid hexasodium salt) and PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) on GABA-currents in isolated hippocampal neurons. We found that NF279 (20 µM) and PPADS (50 µM) decreased GABA currents : NF279 – to ~ 62% ; PPADS to ~ 71% respectively. Additionally, we have confirmed earlier observation regarding suppressing effect of suramin (20 µM) on GABA-currents. We conclude that interpretation of data obtained using relatively high concentrations of NF279, PPADS and suramin for determining the functional role P2X receptor in complex neural networks should be careful. Our results are also essential for improving the selectivity of P2X- receptor antagonists versus GABA-receptors." @default.
- W2189492707 created "2016-06-24" @default.
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- W2189492707 date "2015-01-01" @default.
- W2189492707 modified "2023-09-26" @default.
- W2189492707 title "SEVERAL P2X RECEPTOR ANTAGONISTS, INCLUDING NF279 AND PPADS SUPPRESS GABA RESPONSES IN ISOLATED HIPPOCAMPAL NEURONS." @default.
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