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• W2189511683 abstract "Summary The objective of this study was to study the antidepressant activity of imipramine, amitryptiline, fluoxetine, and trazodone in alloxan-induced diabetes in rats The acute and chronic effects of imipramine (10 mg/kg, i.p.), amitryptiline (10 mg/kg, i.p.), fluoxetine (10 mg/kg, i.p.), and trazodone (10 mg/kg, i.p.] were studied in different glycemic conditions using forced swim test, tail suspension test and reserpine antagonism. Antidepressant treatment resulted in a significant (P<0.05) increase in blood glucose level in mice and significantly (P<0.05) decreased total duration of immobility in all acute studies. A significant correlation between blood glucose level and antidepressant activity was observed in forced swim test and tail suspension test in euglycemic and hyperglycemic conditions. Antidepressants in combination with alloxan resulted in significant (P<0.05) increase in blood glucose level and significantly (P<0.05) decreased duration of immobility. Antidepressants significantly (P<0.05) antagonized reserpine induced hypothermia. The study reveals a good correlation between blood glucose level and antidepressant activity amongst various antidepressants." @default.
• W2189511683 created "2016-06-24" @default.
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• W2189511683 date "2008-01-01" @default.
• W2189511683 modified "2023-09-27" @default.
• W2189511683 title "ALLOXAN-INDUCED DIABETES POTENTIATES ANTIDEPRESSANT ACTIVITY IN RATS" @default.
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