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- W2189525665 abstract "The fitting routine is robust and generally converges to a solution. The residual is usually small (Fig. 2) and reproducibility is in the range of physiological changes for the predominant singlets. Metabolites with a Cramer-Rao lower bound of more than 20% were excluded. The concentration ratios to creatine (mean ± standard deviation; number of included spectra) for the volunteers are: NAA/NAAG 1.65±0.16; n=27, total choline 0.28±0.04; n=27, glutamate 1.77±0.49; n=27, myo-inositol 1.19±0.39; n=27, glutathione 0.60±0.31; n=27, glycine 0.14±0.06; n=23, scyllo-inositol 0.046±0.024; n=20, glucose 0.39±0.25; n=12, alanine 0.22±0.12. High inter-subject standard deviations (around 100%) with many exclusions due to too high CramerRao bounds were found for the other metabolites included in the fit, namely aspartate, GABA, glutamine, lactate, phosphoethanolamine and taurine. The T2 relaxation times are directly given by the line widths in the indirect dimension. The times range from 60ms to 270 ms with standard deviations of 15% to around 50%. Metabolites with a long T2 include the predominant singlets. Most of the other metabolites decay in less than 100 ms. The agreement of the averaged concentration ratios between the 2D fit and LCModel is excellent for the predominant singlets; NAA/NAAG is 9% and total choline 7% higher with 2D fitting. The concentrations determined with 2D fitting are consistently higher for glutamate (78%), glutathione (110%) and myo-inositol (81%). The other metabolites are not reliably quantified through LCModel at this field strength." @default.
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- W2189525665 date "2005-01-01" @default.
- W2189525665 modified "2023-09-24" @default.
- W2189525665 title "Two-Dimensional J-resolved Spectroscopy Fitting" @default.
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