Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189532224> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2189532224 endingPage "F436" @default.
- W2189532224 startingPage "F427" @default.
- W2189532224 abstract "Uridine uptake was investigated in microdissected segments from the entire length of tubules from normal rabbit kidneys and the effect DOCA treatment was studied. Uridine uptake was measured after in vitro incubation of kidney pyramids with [14C]uridine (0.25 mM). Determinations were done on intact segments, and also using TCA precipitation on both the acid-soluble fraction considered as representative of the pyrimidine nucleoside precursor pool and the acid-insoluble one containing the precipitated nucleic acids. In normal rabbits the fraction of uridine incorporated in the insoluble fraction represented about 5% of that in the soluble one for all segments. Maximal values were found in the distal convoluted tubule (DCT) and the connecting tubule (CNT), where uridine uptake was two- to fourfold higher than in other segments. After DOCA treatment, a significant increase in uridine uptake in the soluble fraction was present in the cortical collecting (CCT) (+90%, P less than 0.001) and medullary collecting tubules (MCT) (+63%, P less than 0.05) when values were corrected for the cellular swelling induced by DOCA in all segments. An even more marked rise in uridine incorporation was observed in the insoluble fraction of the DCT (+88%, P less than 0.05), CCT (+291%, P less than 0.001), and MCT (+422%, P less than 0.05). These results indicate that 1) the level of uridine uptake in soluble and insoluble fractions widely differs along the tubular length of the normal rabbit nephron; and 2) DOCA treatment induces an increase of uridine incorporation in both the pyrimidine precursor pool and nucleic acids of the collecting tubule, known to be the target site for corticosteroid hormones." @default.
- W2189532224 created "2016-06-24" @default.
- W2189532224 creator A5001718959 @default.
- W2189532224 date "1984-04-01" @default.
- W2189532224 modified "2023-10-14" @default.
- W2189532224 title "Heterogeneity of uridine incorporation along the rabbit nephron. II. Effect of DOCA" @default.
- W2189532224 doi "https://doi.org/10.1152/ajprenal.1984.246.4.f427" @default.
- W2189532224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6720900" @default.
- W2189532224 hasPublicationYear "1984" @default.
- W2189532224 type Work @default.
- W2189532224 sameAs 2189532224 @default.
- W2189532224 citedByCount "4" @default.
- W2189532224 crossrefType "journal-article" @default.
- W2189532224 hasAuthorship W2189532224A5001718959 @default.
- W2189532224 hasConcept C104317684 @default.
- W2189532224 hasConcept C126322002 @default.
- W2189532224 hasConcept C134018914 @default.
- W2189532224 hasConcept C149629883 @default.
- W2189532224 hasConcept C159641895 @default.
- W2189532224 hasConcept C185592680 @default.
- W2189532224 hasConcept C202751555 @default.
- W2189532224 hasConcept C2776543447 @default.
- W2189532224 hasConcept C2780091579 @default.
- W2189532224 hasConcept C2780498532 @default.
- W2189532224 hasConcept C2781231759 @default.
- W2189532224 hasConcept C2781259782 @default.
- W2189532224 hasConcept C43617362 @default.
- W2189532224 hasConcept C55493867 @default.
- W2189532224 hasConcept C67705224 @default.
- W2189532224 hasConcept C71924100 @default.
- W2189532224 hasConcept C86803240 @default.
- W2189532224 hasConceptScore W2189532224C104317684 @default.
- W2189532224 hasConceptScore W2189532224C126322002 @default.
- W2189532224 hasConceptScore W2189532224C134018914 @default.
- W2189532224 hasConceptScore W2189532224C149629883 @default.
- W2189532224 hasConceptScore W2189532224C159641895 @default.
- W2189532224 hasConceptScore W2189532224C185592680 @default.
- W2189532224 hasConceptScore W2189532224C202751555 @default.
- W2189532224 hasConceptScore W2189532224C2776543447 @default.
- W2189532224 hasConceptScore W2189532224C2780091579 @default.
- W2189532224 hasConceptScore W2189532224C2780498532 @default.
- W2189532224 hasConceptScore W2189532224C2781231759 @default.
- W2189532224 hasConceptScore W2189532224C2781259782 @default.
- W2189532224 hasConceptScore W2189532224C43617362 @default.
- W2189532224 hasConceptScore W2189532224C55493867 @default.
- W2189532224 hasConceptScore W2189532224C67705224 @default.
- W2189532224 hasConceptScore W2189532224C71924100 @default.
- W2189532224 hasConceptScore W2189532224C86803240 @default.
- W2189532224 hasIssue "4" @default.
- W2189532224 hasLocation W21895322241 @default.
- W2189532224 hasLocation W21895322242 @default.
- W2189532224 hasOpenAccess W2189532224 @default.
- W2189532224 hasPrimaryLocation W21895322241 @default.
- W2189532224 hasRelatedWork W1610650548 @default.
- W2189532224 hasRelatedWork W19451483 @default.
- W2189532224 hasRelatedWork W2020959757 @default.
- W2189532224 hasRelatedWork W2042033030 @default.
- W2189532224 hasRelatedWork W2044943066 @default.
- W2189532224 hasRelatedWork W2070511355 @default.
- W2189532224 hasRelatedWork W2082380108 @default.
- W2189532224 hasRelatedWork W2127085070 @default.
- W2189532224 hasRelatedWork W2189532224 @default.
- W2189532224 hasRelatedWork W2400445066 @default.
- W2189532224 hasVolume "246" @default.
- W2189532224 isParatext "false" @default.
- W2189532224 isRetracted "false" @default.
- W2189532224 magId "2189532224" @default.
- W2189532224 workType "article" @default.