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- W2189536941 abstract "Metformin hydrochloride (MH) is an oral hypoglycemic agent and a high-dose drug that has poor flow and compression properties and thus presents formulation problems. In this study the tabletting properties of MH agglomerates prepared by spherical crystallization techniques, i.e a spherically agglomeration method was investigated. The flow and packing properties of agglomerates, represented in terms of the angle of repose and change in tapping density, were much improved by this technique compared with those of conventional crystals due to the spherical shape and smooth surface. Furthermore, spherical agglomerates possessed superior strength characteristics to conventional crystals and were compressed into compacts having considerable hardness without capping at high compaction pressure. From the calculated Heckel’s parameter, it was demonstrated that the spherical agglomerates of the drug showed better particle arrangement in the compression stages. Kawakita analysis revealed better packability of the agglomerated drug compared to the conventional drug." @default.
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- W2189536941 date "2011-01-01" @default.
- W2189536941 modified "2023-09-27" @default.
- W2189536941 title "DEVELOPMENT OF DIRECTLY COMPRESSIBLE METFORMIN HYDROCHLORIDE TABLETS Research Article" @default.
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