FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189542167> ?p ?o ?g. }

• W2189542167 abstract "Osteoporosis and periodontitis are widespread diseases among male and female population, whose incidence increases with aging. The basic pathogenic mechanism of osteoporosis and periodontal disease is a bone resorption with increased production of proinflammatory cytokines: interleukin IL-1β, IL-6, TNF-α and RANKL. The discovery of receptor activator of NF-κB (RANK), its ligand (RANKL) and osteoprotegerin (OPG) has contributed to the understanding of bone biology and mechanisms of osteoclastogenesis. RANKL-RANK interaction is critical for differentiation and maintenance of osteoclast activity. The balance between RANKL and OPG regulates osteoclastogenesis, and thus bone resorption. The disruption of the RANKL/RANK/OPG axis leads to an imbalance between bone formation and bone resorption; therefore, it is responsible for the disturbed bone homeostasis. Loss of bone density associated with decreased estrogen levels is the result of a significant increase in osteoclast activity. Menopausal bone loss may be the result of osteoclast overactivation by proinflammatory cytokines and it is associated with reduced estrogen levels. The lack of estrogen can lead to worsening of periodontal disease and it increases the rate of the gingival connective tissue damage by stimulating the synthesis of several cytokines responsible for bone resorption. Cytokines and RANKL/OPG signaling pathway involved in the pathogenesis of osteoporosis and periodontal disease can lead to the activation of osteoclasts and the stimulation of bone resorption. These findings in the future may improve the usual treatment of periodontal disease and osteoporosis therapy, including the inhibition of proinflammatory mediators and osteoclast activity with the additional use of anti-inflammatory drugs. This involves blocking the binding of different stimulating factors to their receptors on osteoclast precursors, particularly RANKL and development of new more selective drugs with fewer side effects that would act as an anti-cytokines preventing the binding of cytokines to their receptors. Acta Medica Medianae 2012;51(4):51-57." @default.
• W2189542167 created "2016-06-24" @default.
• W2189542167 creator A5017652431 @default.
• W2189542167 creator A5025268339 @default.
• W2189542167 creator A5030110560 @default.
• W2189542167 creator A5042759464 @default.
• W2189542167 creator A5076249227 @default.
• W2189542167 creator A5083700388 @default.
• W2189542167 date "2012-01-01" @default.
• W2189542167 modified "2023-09-23" @default.
• W2189542167 title "IMMUNOPATHOGENETIC MECHANISMS OF PERIODONTAL DISEASE AND POSTMENOPAUSAL OSTEOPOROSIS" @default.
• W2189542167 cites W1529510901 @default.
• W2189542167 cites W1973895104 @default.
• W2189542167 cites W1981803131 @default.
• W2189542167 cites W1989860636 @default.
• W2189542167 cites W1991762596 @default.
• W2189542167 cites W2000687864 @default.
• W2189542167 cites W2001060821 @default.
• W2189542167 cites W2003284223 @default.
• W2189542167 cites W2003423562 @default.
• W2189542167 cites W2010296043 @default.
• W2189542167 cites W2012369312 @default.
• W2189542167 cites W2015527055 @default.
• W2189542167 cites W2022775704 @default.
• W2189542167 cites W2030259128 @default.
• W2189542167 cites W2034959911 @default.
• W2189542167 cites W2048299560 @default.
• W2189542167 cites W2048961393 @default.
• W2189542167 cites W2055166353 @default.
• W2189542167 cites W2058362889 @default.
• W2189542167 cites W2060660496 @default.
• W2189542167 cites W2069811152 @default.
• W2189542167 cites W2079588364 @default.
• W2189542167 cites W2085675651 @default.
• W2189542167 cites W2087684098 @default.
• W2189542167 cites W2097814981 @default.
• W2189542167 cites W2097913481 @default.
• W2189542167 cites W2101715232 @default.
• W2189542167 cites W2102079742 @default.
• W2189542167 cites W2110555227 @default.
• W2189542167 cites W2123700432 @default.
• W2189542167 cites W2124462796 @default.
• W2189542167 cites W2124802339 @default.
• W2189542167 cites W2125168145 @default.
• W2189542167 cites W2126446849 @default.
• W2189542167 cites W2129651548 @default.
• W2189542167 cites W2132019676 @default.
• W2189542167 cites W2132897787 @default.
• W2189542167 cites W2132933661 @default.
• W2189542167 cites W2143520063 @default.
• W2189542167 cites W2151706936 @default.
• W2189542167 cites W2158952295 @default.
• W2189542167 cites W2166196230 @default.
• W2189542167 cites W2185998141 @default.
• W2189542167 cites W2188503857 @default.
• W2189542167 cites W2313767081 @default.
• W2189542167 cites W2328900081 @default.
• W2189542167 cites W2405898224 @default.
• W2189542167 hasPublicationYear "2012" @default.
• W2189542167 type Work @default.
• W2189542167 sameAs 2189542167 @default.
• W2189542167 citedByCount "2" @default.
• W2189542167 countsByYear W21895421672015 @default.
• W2189542167 countsByYear W21895421672018 @default.
• W2189542167 crossrefType "journal-article" @default.
• W2189542167 hasAuthorship W2189542167A5017652431 @default.
• W2189542167 hasAuthorship W2189542167A5025268339 @default.
• W2189542167 hasAuthorship W2189542167A5030110560 @default.
• W2189542167 hasAuthorship W2189542167A5042759464 @default.
• W2189542167 hasAuthorship W2189542167A5076249227 @default.
• W2189542167 hasAuthorship W2189542167A5083700388 @default.
• W2189542167 hasConcept C126322002 @default.
• W2189542167 hasConcept C199343813 @default.
• W2189542167 hasConcept C2776541429 @default.
• W2189542167 hasConcept C2776886416 @default.
• W2189542167 hasConcept C2779134260 @default.
• W2189542167 hasConcept C2992452445 @default.
• W2189542167 hasConcept C3018571302 @default.
• W2189542167 hasConcept C3018603563 @default.
• W2189542167 hasConcept C71924100 @default.
• W2189542167 hasConceptScore W2189542167C126322002 @default.
• W2189542167 hasConceptScore W2189542167C199343813 @default.
• W2189542167 hasConceptScore W2189542167C2776541429 @default.
• W2189542167 hasConceptScore W2189542167C2776886416 @default.
• W2189542167 hasConceptScore W2189542167C2779134260 @default.
• W2189542167 hasConceptScore W2189542167C2992452445 @default.
• W2189542167 hasConceptScore W2189542167C3018571302 @default.
• W2189542167 hasConceptScore W2189542167C3018603563 @default.
• W2189542167 hasConceptScore W2189542167C71924100 @default.
• W2189542167 hasLocation W21895421671 @default.
• W2189542167 hasOpenAccess W2189542167 @default.
• W2189542167 hasPrimaryLocation W21895421671 @default.
• W2189542167 hasRelatedWork W2059226678 @default.
• W2189542167 hasRelatedWork W2184875878 @default.
• W2189542167 hasRelatedWork W2223084035 @default.
• W2189542167 hasRelatedWork W2297062172 @default.
• W2189542167 hasRelatedWork W2337317935 @default.
• W2189542167 hasRelatedWork W2358010641 @default.
• W2189542167 hasRelatedWork W2378834500 @default.
• W2189542167 hasRelatedWork W3049075496 @default.

• next