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- W2189555000 abstract "Recent discoveries in the biological sciences have revealed that nitric oxide has a number of important physiological functions and is also implicated in a number of diseases. This realisation has provided a stimulus for nitric oxide related drug research and development. In this review new work aimed at the development of potential therapeutic use of ruthenium compounds, particularly ruthenium( III) polyaminocarboxylate, JM1226, is presented and discussed in the context of the chemistry and biology of nitric oxide. Based on these studies, prospects for the further development of JM1226 appear promising. Nitric oxide (nitrogen monoxide, NO) is commonly viewed as being a toxic environmental pollutant. This has been the major motivation for research into both its chemical reactivity and biological activity. Nitric oxide is one of the major emissions from car exhausts and for many scientists the co-ordination chemistry of the platinum group metals and nitric oxide is synonymous with the development of the automobile catalytic converter. However, new developments in the biological sciences have now allowed us to look at some of the well known chemistry of transition metals and nitric oxide from a different perspective." @default.
- W2189555000 created "2016-06-24" @default.
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- W2189555000 date "1995-01-01" @default.
- W2189555000 modified "2023-09-27" @default.
- W2189555000 title "Ruthenium, Nitric Oxide and Disease A NOVEL INORGANIC CHEMISTRY APPROACH TO DRUG DESIGN" @default.
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