Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189555546> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2189555546 endingPage "7" @default.
- W2189555546 startingPage "391" @default.
- W2189555546 abstract "The multi tumor suppressor genes MTS1 (CDKN2, p16INK4A) and MTS2 (CDKN1, p15INK4B) located at 9p21-22 are inactivated in some human cancers via several mechanisms including deletion and hypermethylation. In hematological malignancies, deletion of p16/p15 locus has been shown to be highly specific to lymphoid malignancies, and more particularly to T-cell acute lymphoblastic leukemia (TALL). We have investigated the deletion, methylation and p16 protein expression status of MTS1 in Tcell childhood acute lymphoblastic leukemia (19 cases) and cell lines[11]. On Southern blot homozygous deletions or hemizygous deletion with rearangement were detected in 4/19 T-ALL. The expression of p16 protein was not observed on Western blot in 4/15 T-ALL with intact p16 gene. The p16 gene was methylated 3/15 in T-ALL. Only one of three expressed p16 protein. The other 11/15 T-ALL had p16 protein expression but different level. Loss of MTS1 was observed in 3/11 cell lines. Cell line with MTS1 gene had p16 protein expression in 6/8. After treatment with the demethylating agent (5-AzoCyt) RD cell line showed p16 expression. This has not been observed with the other cell lines. Thus hypermethylation of MTS1 is rare in childhood T-ALL. Although inactivation of MTS1 by deletion is common in T-ALL and cell lines. Furthermore our data show that the p16 gene inactivation by hypermethylation and deletion may play a role in the leukemogenesis." @default.
- W2189555546 created "2016-06-24" @default.
- W2189555546 creator A5006467243 @default.
- W2189555546 creator A5042585088 @default.
- W2189555546 creator A5056109106 @default.
- W2189555546 date "2002-09-05" @default.
- W2189555546 modified "2023-10-11" @default.
- W2189555546 title "Variable Expression and Hypermethylation of p16 Gene in Patients with T-ALL and Cell Lines." @default.
- W2189555546 cites W1531180106 @default.
- W2189555546 cites W1560943589 @default.
- W2189555546 cites W1583984382 @default.
- W2189555546 cites W1586414137 @default.
- W2189555546 cites W1616778816 @default.
- W2189555546 cites W1977706798 @default.
- W2189555546 cites W1978057094 @default.
- W2189555546 cites W2003363961 @default.
- W2189555546 cites W2066848701 @default.
- W2189555546 cites W2089371288 @default.
- W2189555546 cites W2116114777 @default.
- W2189555546 cites W2122580718 @default.
- W2189555546 cites W2130198345 @default.
- W2189555546 cites W2136422121 @default.
- W2189555546 cites W2141566331 @default.
- W2189555546 cites W2150162153 @default.
- W2189555546 cites W2300127060 @default.
- W2189555546 cites W2470517880 @default.
- W2189555546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27264975" @default.
- W2189555546 hasPublicationYear "2002" @default.
- W2189555546 type Work @default.
- W2189555546 sameAs 2189555546 @default.
- W2189555546 citedByCount "1" @default.
- W2189555546 countsByYear W21895555462018 @default.
- W2189555546 crossrefType "journal-article" @default.
- W2189555546 hasAuthorship W2189555546A5006467243 @default.
- W2189555546 hasAuthorship W2189555546A5042585088 @default.
- W2189555546 hasAuthorship W2189555546A5056109106 @default.
- W2189555546 hasConcept C104317684 @default.
- W2189555546 hasConcept C150194340 @default.
- W2189555546 hasConcept C153911025 @default.
- W2189555546 hasConcept C190727270 @default.
- W2189555546 hasConcept C2778264664 @default.
- W2189555546 hasConcept C2778461978 @default.
- W2189555546 hasConcept C2779277951 @default.
- W2189555546 hasConcept C33288867 @default.
- W2189555546 hasConcept C502942594 @default.
- W2189555546 hasConcept C54355233 @default.
- W2189555546 hasConcept C555283112 @default.
- W2189555546 hasConcept C81885089 @default.
- W2189555546 hasConcept C84597430 @default.
- W2189555546 hasConcept C86803240 @default.
- W2189555546 hasConceptScore W2189555546C104317684 @default.
- W2189555546 hasConceptScore W2189555546C150194340 @default.
- W2189555546 hasConceptScore W2189555546C153911025 @default.
- W2189555546 hasConceptScore W2189555546C190727270 @default.
- W2189555546 hasConceptScore W2189555546C2778264664 @default.
- W2189555546 hasConceptScore W2189555546C2778461978 @default.
- W2189555546 hasConceptScore W2189555546C2779277951 @default.
- W2189555546 hasConceptScore W2189555546C33288867 @default.
- W2189555546 hasConceptScore W2189555546C502942594 @default.
- W2189555546 hasConceptScore W2189555546C54355233 @default.
- W2189555546 hasConceptScore W2189555546C555283112 @default.
- W2189555546 hasConceptScore W2189555546C81885089 @default.
- W2189555546 hasConceptScore W2189555546C84597430 @default.
- W2189555546 hasConceptScore W2189555546C86803240 @default.
- W2189555546 hasIssue "3" @default.
- W2189555546 hasLocation W21895555461 @default.
- W2189555546 hasOpenAccess W2189555546 @default.
- W2189555546 hasPrimaryLocation W21895555461 @default.
- W2189555546 hasRelatedWork W1969774671 @default.
- W2189555546 hasRelatedWork W1993354505 @default.
- W2189555546 hasRelatedWork W2043933892 @default.
- W2189555546 hasRelatedWork W2083522244 @default.
- W2189555546 hasRelatedWork W2093682184 @default.
- W2189555546 hasRelatedWork W2097596835 @default.
- W2189555546 hasRelatedWork W2120433144 @default.
- W2189555546 hasRelatedWork W2128847669 @default.
- W2189555546 hasRelatedWork W2252610283 @default.
- W2189555546 hasRelatedWork W4283027398 @default.
- W2189555546 hasVolume "19" @default.
- W2189555546 isParatext "false" @default.
- W2189555546 isRetracted "false" @default.
- W2189555546 magId "2189555546" @default.
- W2189555546 workType "article" @default.