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- W2189557816 abstract "SUMMARY Daily useof7gL-tryptophan and70mg pyridoxine for14daysledtono deterioration ofobjectively measured manual motorskills ina small group ofpatients withHuntington's chorea. Reportspreviously published suggest that serotonin metabolites areassociated withthe pathogenesis ofchorea (Faurbye, 1970; Klawans, 1970), buttheir precise roleisyettobeestablished. Conflicting reports havefollowed experimentsusing daily dosesoftryptophan given orally. OepenandOepen(1969) foundno deterioration inthemotorperformance of patients withHuntington's chorea given 10gof L-tryptophan daily, while smaller doses given by Barbeau produced choreiform movementsin patients withjuvenile Huntington's disease and inother choreiform patients (Barbeau, 1969). Another serotonin precursor, 5-hydroxy-tryptophan,given orally wassaidtoaggravate the severity ofchoreiform movementsinpatients withHuntington's chorea(Lee, Markham, and Clark, 1967). Oliphant, Evans, andForrest using bothtryptophan and5-hydroxy tryptophan foundno increase inabnormalmovements." @default.
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- W2189557816 date "1972-01-01" @default.
- W2189557816 modified "2023-09-27" @default.
- W2189557816 title "Huntington's chorea andtryptophan" @default.
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