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- W2189564897 abstract "A novelmicrofluidic coculture systemwas developed formoreaccurately modelling theinteraction of macrophages andosteoblasts. Themicrofluidic coculture chip wasfabricated byCO2laser direct-writing onpoly(methyl methacrylate) (PMMA)andwasdesigned toseparate twocell typesbyamicrochannel, while permitting cellular mediato transfer. Thereleased inflammatory cytokines (ex:IL-llp, TNF-a)activated inupstream macrophages flowthrough a microfluidic systemand generate linearconcentration gradients indown-stream wellsandinducedown-stream osteoblasts torelease prostaglandin E2 (PCE2), whichis well-known asaboneresorption marker. Colorimetric MTT assaywasusedtoexamine theosteoblast viability. This system canbeusedtoevaluate thecell-cell interaction while physically separate theinteracting cells. Keywords- Microfluidic, coculture, concentration gradients" @default.
- W2189564897 created "2016-06-24" @default.
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- W2189564897 date "2005-01-01" @default.
- W2189564897 modified "2023-09-27" @default.
- W2189564897 title "AMicrofluidic Coculture System forCell-Cell Interaction Study" @default.
- W2189564897 hasPublicationYear "2005" @default.
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