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- W2189567416 abstract "The elastic properties of the stratum corneum have been examined by many investigators, but the morphological evidence for changes in the structure of stratum corneum cohesive elements, lipids and desmosomes, during mechanical extension remains sparse. Additionally, little is known of the effect of mechanical stress on stratum corneum water barrier function. In this study we have examined in detail changes in the structure of the stratum corneum intercellular lipids and desmosomes during linear extension studies on isolated stratum corneum in vitro. Ultrastructural changes have been investigated by electron microscopy, and barrier function has been assessed by measuring water loss through the tissue. Initially, at low extensions of the stratum corneum the structure of the intercellular bilayer lipids appeared normal, during further extension their membrane structure became disrupted, and with continued extension they became progressively disorganized. Desmosomes, by comparison, were more resilient structures, only being perturbed after large extensions during which intercorneocyte desmosomal links were observed to rupture just before the complete fracture of the tissue. These events were associated with increased water loss through the stratum corneum. If these in vitro events are paralleled in vivo, it appears that stratum corneum lipids are sufficiently fluid to maintain barrier function during small extensions of the skin surface. However, following large extensions the structural changes could lead to perturbed water barrier function, desmosome rupture, and aberrant desquamation, resulting in the appearance of xerotic skin conditions." @default.
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- W2189567416 date "1995-01-01" @default.
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- W2189567416 title "Changes in stratum corneum lipid and desmosome structure together with water barrier function during mechanical stress" @default.
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