Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189575346> ?p ?o ?g. }
- W2189575346 endingPage "495" @default.
- W2189575346 startingPage "482" @default.
- W2189575346 abstract "Sphingolipids such as ceramide, sphingosine-1-phosphate and sphingomyelin have been emerging as bioactive lipids since ceramide was reported to play a role in human leukemia HL-60 cell differentiation and death. Recently, it is well-known that ceramide acts as an inducer of cell death, that sphingomyelin works as a regulator for microdomain function of the cell membrane, and that sphingosine-1-phosphate plays a role in cell survival/proliferation. The lipids are metabolized by the specific enzymes, and each metabolite could be again returned to the original form by the reverse action of the different enzyme or after a long journey of many metabolizing/synthesizing pathways. In addition, the metabolites may serve as reciprocal bio-modulators like the rheostat between ceramide and sphingosine-1-phosphate. Therefore, the change of lipid amount in the cells, the subcellular localization and the downstream signal in a specific subcellular organelle should be clarified to understand the pathobiological significance of sphingolipids when extracellular stimulation induces a diverse of cell functions such as cell death, proliferation and migration. In this review, we focus on how sphingolipids and their metabolizing enzymes cooperatively exert their function in proliferation, migration, autophagy and death of hematopoetic cells, and discuss the way developing a novel therapeutic device through the regulation of sphingolipids for effectively inhibiting cell proliferation and inducing cell death in hematological malignancies such as leukemia, malignant lymphoma and multiple myeloma." @default.
- W2189575346 created "2016-06-24" @default.
- W2189575346 creator A5069353800 @default.
- W2189575346 creator A5079585951 @default.
- W2189575346 creator A5091657418 @default.
- W2189575346 date "2015-05-22" @default.
- W2189575346 modified "2023-09-27" @default.
- W2189575346 title "Role of Sphingolipids and Metabolizing Enzymes in Hematological Malignancies" @default.
- W2189575346 cites W1256777839 @default.
- W2189575346 cites W1515009017 @default.
- W2189575346 cites W1566441785 @default.
- W2189575346 cites W157208926 @default.
- W2189575346 cites W1599883407 @default.
- W2189575346 cites W1635474458 @default.
- W2189575346 cites W1859298280 @default.
- W2189575346 cites W1876657983 @default.
- W2189575346 cites W1882088804 @default.
- W2189575346 cites W1965762690 @default.
- W2189575346 cites W1966330905 @default.
- W2189575346 cites W1966911854 @default.
- W2189575346 cites W1967950972 @default.
- W2189575346 cites W1968076808 @default.
- W2189575346 cites W1972408290 @default.
- W2189575346 cites W1973653103 @default.
- W2189575346 cites W1975342895 @default.
- W2189575346 cites W1975748957 @default.
- W2189575346 cites W1978465583 @default.
- W2189575346 cites W1978777932 @default.
- W2189575346 cites W1979321726 @default.
- W2189575346 cites W1979933119 @default.
- W2189575346 cites W1983079076 @default.
- W2189575346 cites W1983571376 @default.
- W2189575346 cites W1986394981 @default.
- W2189575346 cites W1986585212 @default.
- W2189575346 cites W1993667361 @default.
- W2189575346 cites W1993956461 @default.
- W2189575346 cites W1994679471 @default.
- W2189575346 cites W1996006903 @default.
- W2189575346 cites W1996784003 @default.
- W2189575346 cites W1997469380 @default.
- W2189575346 cites W1997985605 @default.
- W2189575346 cites W2000468141 @default.
- W2189575346 cites W2001956269 @default.
- W2189575346 cites W2002311959 @default.
- W2189575346 cites W2002681098 @default.
- W2189575346 cites W2003522137 @default.
- W2189575346 cites W2003575648 @default.
- W2189575346 cites W2003717464 @default.
- W2189575346 cites W2004293325 @default.
- W2189575346 cites W2004407092 @default.
- W2189575346 cites W2007500485 @default.
- W2189575346 cites W2007744969 @default.
- W2189575346 cites W2009507839 @default.
- W2189575346 cites W2014523419 @default.
- W2189575346 cites W2014552171 @default.
- W2189575346 cites W2015736508 @default.
- W2189575346 cites W2017729786 @default.
- W2189575346 cites W2018146992 @default.
- W2189575346 cites W2018474075 @default.
- W2189575346 cites W2018509808 @default.
- W2189575346 cites W2019523579 @default.
- W2189575346 cites W2019827750 @default.
- W2189575346 cites W2020913731 @default.
- W2189575346 cites W2021341096 @default.
- W2189575346 cites W2021433993 @default.
- W2189575346 cites W2022497999 @default.
- W2189575346 cites W2022575732 @default.
- W2189575346 cites W2027027613 @default.
- W2189575346 cites W2031380298 @default.
- W2189575346 cites W2032315776 @default.
- W2189575346 cites W2033859595 @default.
- W2189575346 cites W2036143010 @default.
- W2189575346 cites W2036262978 @default.
- W2189575346 cites W2037559271 @default.
- W2189575346 cites W2038891352 @default.
- W2189575346 cites W2039321321 @default.
- W2189575346 cites W2039775874 @default.
- W2189575346 cites W2040571102 @default.
- W2189575346 cites W2041922728 @default.
- W2189575346 cites W2043466478 @default.
- W2189575346 cites W2044807782 @default.
- W2189575346 cites W2046607062 @default.
- W2189575346 cites W2049105906 @default.
- W2189575346 cites W2049914201 @default.
- W2189575346 cites W2050243165 @default.
- W2189575346 cites W2051485704 @default.
- W2189575346 cites W2054207130 @default.
- W2189575346 cites W2056926817 @default.
- W2189575346 cites W2062376915 @default.
- W2189575346 cites W2065877465 @default.
- W2189575346 cites W2066892631 @default.
- W2189575346 cites W2072471408 @default.
- W2189575346 cites W2076226373 @default.
- W2189575346 cites W2076743846 @default.
- W2189575346 cites W2077179584 @default.
- W2189575346 cites W2077609848 @default.
- W2189575346 cites W2078549633 @default.
- W2189575346 cites W2079670251 @default.