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- W2189583652 abstract "To investigate the direct role of interleukin (IL) 6 in the development of rheumatoid arthritis, IL-6- deficient (IL-6 2y2) mice were backcrossed for eight gener- ations into C57BLy6 mice, a strain of mice with a genetic background of susceptibility for antigen-induced arthritis (AIA). Both histological and immunological comparisons were made between IL-6-deficient (IL-6 2y2) mice and wild-type (IL-6 1y1) littermates after the induction of AIA. Although all IL-6 1y1 mice developed severe arthritis, only mild arthritis was observed in IL-6 2y2 mice. Safranin O staining demonstrated that articular cartilage was well pre- served in IL-6 2y2 mice, whereas it was destroyed completely in IL-6 1y1 mice. In addition, comparable mRNA expression for both IL-1b and tumor necrosis factor a, but not for IL-6, was detected in the inf lamed joints of IL-6 2y2 mice, suggesting that IL-6 may play a more crucial role in cartilage destruction than either IL-1b or tumor necrosis factor a .I n immunological comparisons, both antigen-specific in vitro proliferative response in lymph node cells and in vivo antibody production were elicited in IL-6 2y2 mice, but they were reduced to less than half of that found in IL-6 1y1 mice. Lymph node cells of IL-6 2y2 mice produced many more Th2 cytokines than did IL-6 1y1 mice with either antigen-specific or nonspecific stimulation in in vitro culture. Taken together, these results indicate that IL-6 may play a key role in the development of AIA at the inductive as well as the effector phase, and the blockade of IL-6 is possibly beneficial in the treatment of rheumatoid arthritis." @default.
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- W2189583652 date "1998-01-01" @default.
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- W2189583652 title "Interleukin 6 plays a key role in the development of antigen-induced arthritis (rheumatoid arthritisyproinf lammatory cytokine)" @default.
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