FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W218958693> ?p ?o ?g. }

• W218958693 endingPage "35" @default.
• W218958693 startingPage "28" @default.
• W218958693 abstract "Ammonia is a metabolite that, at high concentrations, is implicated in neurological disorders, such as hepatic encephalopathy (HE), which is associated with acute or chronic liver failure. Astrocytes are considered the primary target of ammonia toxicity in the central nervous system (CNS) because glutamine synthetase (GS), responsible for ammonia metabolism in CNS, is an astrocytic enzyme. Thus, neuronal dysfunction has been associated as secondary to astrocytic impairment. However, we demonstrated that ammonia can induce direct effects on neuronal cells. The cell viability was decreased by ammonia in SH-SY5Y cells and cerebellar granule neurons. In addition, ammonia induced increased reactive oxygen species (ROS) production and decreased GSH intracellular content, the main antioxidant in CNS. As ammonia neurotoxicity is strongly associated with oxidative stress, we also investigated the potential neuroprotective roles of the antioxidants, resveratrol (RSV) and lipoic acid (LA), against ammonia toxicity in cerebellar granule neurons. RSV and LA were able to prevent the oxidative damage induced by ammonia, maintaining the levels of ROS production and GSH close to basal values. Both antioxidants also decreased ROS production and increased GSH content under basal conditions (in the absence of ammonia). Moreover, we showed that heme oxygenase 1 (HO1), a protein associated with protection against stress conditions, is involved in the beneficial effects of RSV and LA in cerebellar granule neurons. Thus, this study reinforces the neuroprotective effects of RSV and LA. Although more studies in vivo are required, RSV and LA could represent interesting therapeutic strategies for the management of HE." @default.
• W218958693 created "2016-06-24" @default.
• W218958693 creator A5002744170 @default.
• W218958693 creator A5038194292 @default.
• W218958693 creator A5040701010 @default.
• W218958693 creator A5077014711 @default.
• W218958693 creator A5077588471 @default.
• W218958693 creator A5085868113 @default.
• W218958693 date "2015-07-01" @default.
• W218958693 modified "2023-10-01" @default.
• W218958693 title "Ammonia-induced oxidative damage in neurons is prevented by resveratrol and lipoic acid with participation of heme oxygenase 1" @default.
• W218958693 cites W1162433512 @default.
• W218958693 cites W1504251053 @default.
• W218958693 cites W1608390320 @default.
• W218958693 cites W1637392459 @default.
• W218958693 cites W1665055663 @default.
• W218958693 cites W1724227103 @default.
• W218958693 cites W1775749144 @default.
• W218958693 cites W1841517170 @default.
• W218958693 cites W1922292712 @default.
• W218958693 cites W1969260386 @default.
• W218958693 cites W1970038928 @default.
• W218958693 cites W1970426851 @default.
• W218958693 cites W1970718497 @default.
• W218958693 cites W1970836174 @default.
• W218958693 cites W1970851794 @default.
• W218958693 cites W1979662880 @default.
• W218958693 cites W1980687166 @default.
• W218958693 cites W1981279331 @default.
• W218958693 cites W1984089779 @default.
• W218958693 cites W1984716386 @default.
• W218958693 cites W1985697148 @default.
• W218958693 cites W1986729839 @default.
• W218958693 cites W1989117820 @default.
• W218958693 cites W1990498860 @default.
• W218958693 cites W1992257441 @default.
• W218958693 cites W1993712340 @default.
• W218958693 cites W1993839684 @default.
• W218958693 cites W1994662389 @default.
• W218958693 cites W1998104092 @default.
• W218958693 cites W2001019228 @default.
• W218958693 cites W2001808269 @default.
• W218958693 cites W2002536213 @default.
• W218958693 cites W2007258895 @default.
• W218958693 cites W2008366009 @default.
• W218958693 cites W2009517899 @default.
• W218958693 cites W2013926403 @default.
• W218958693 cites W2014665962 @default.
• W218958693 cites W2022202335 @default.
• W218958693 cites W2024679196 @default.
• W218958693 cites W2025104024 @default.
• W218958693 cites W2030531016 @default.
• W218958693 cites W2030913726 @default.
• W218958693 cites W2031795384 @default.
• W218958693 cites W2031879414 @default.
• W218958693 cites W2035918887 @default.
• W218958693 cites W2038062287 @default.
• W218958693 cites W2038513854 @default.
• W218958693 cites W2038926224 @default.
• W218958693 cites W2039840773 @default.
• W218958693 cites W2046747620 @default.
• W218958693 cites W2049521023 @default.
• W218958693 cites W2053318380 @default.
• W218958693 cites W2053400199 @default.
• W218958693 cites W2056409947 @default.
• W218958693 cites W2057488973 @default.
• W218958693 cites W2057943569 @default.
• W218958693 cites W2061027179 @default.
• W218958693 cites W2067767758 @default.
• W218958693 cites W2069575624 @default.
• W218958693 cites W2070263356 @default.
• W218958693 cites W2072184602 @default.
• W218958693 cites W2074948025 @default.
• W218958693 cites W2075972236 @default.
• W218958693 cites W2079250577 @default.
• W218958693 cites W2079388055 @default.
• W218958693 cites W2083165373 @default.
• W218958693 cites W2083957671 @default.
• W218958693 cites W2089425170 @default.
• W218958693 cites W2094107525 @default.
• W218958693 cites W2095443848 @default.
• W218958693 cites W2097423163 @default.
• W218958693 cites W2097898843 @default.
• W218958693 cites W2098559329 @default.
• W218958693 cites W2108468088 @default.
• W218958693 cites W2108995381 @default.
• W218958693 cites W2109348594 @default.
• W218958693 cites W2117188757 @default.
• W218958693 cites W2120505405 @default.
• W218958693 cites W2125863862 @default.
• W218958693 cites W2127165897 @default.
• W218958693 cites W2132481752 @default.
• W218958693 cites W2137598362 @default.
• W218958693 cites W2144463858 @default.
• W218958693 cites W2152668808 @default.
• W218958693 cites W2154587590 @default.
• W218958693 cites W2156813826 @default.
• W218958693 cites W2160453061 @default.

• next