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• W2189593721 abstract "Pneumoconiosis is a pulmonary disease of occupational origin, considered to be highly prevalent among workers exposed to mineral dust, such as silica and asbestos, in the various branches of industrial production. The inhalation of these mineral dust can develop an intense interstitial pulmonary fibrosis, characterized by inflammatory reaction, release of chemotactic factors, production of collagen and consequent formation of granuloma in the lung. Biological indicators may be useful in understanding this inflammatory process of pulmonary disease, in identifying the pre-fibrogenic phase, in monitoring and treating these diseases. It carries out a study of the level of concentration of three cytokines: Tumor Necrosis factor alpha (TNFO), interleukin-1s (IL-1s) and interleukin-6 (IL-6) in pulmonary disease caused by exposure to silica and to asbestos, in pneumoconiosis. The specific objective was to determine their concentration in the blood serum of patients exposed to silica and asbestos and to verify the association of cytokines with exposures and pneumoconiosis. It was studied 161 people, of which 107 workers exposed to mineral dust, 85 exposed to silica and 22 exposed to asbestos, and 54 workers not exposed in the comparison group. For the quantitative determination of TNFI ±, IL-1I² and IL-6, blood was collected from all workers included in the design and the Elisa method was used for the analysis. Significant differences were also found between patients with pneumoconiosis and the group not exposed to the three cytokines at differentiated levels. Analysis of the results did not discriminate the role of cytokines in the pre-fibrotic phase of disease. The results in the subgroup exposed to silica with silicosis did not show elevated levels of IL-6 and TNF, but showed elevated IL-1β levels of cytokines dosed in blood. In the subgroup exposed to asbestosis with asbestosis, there was only an increase in IL-6 levels. In the field of public health, there are still no instruments capable of predicting pathological processes in workers exposed to mineral dust, especially silica and asbestos. The field of study of cytokines and other markers is promising, but so far the only weapon to reduce or eliminate damage from mineral dust in the workplace is the removal of the harmful agent from the environment." @default.
• W2189593721 created "2016-06-24" @default.
• W2189593721 creator A5061194092 @default.
• W2189593721 date "2000-01-01" @default.
• W2189593721 modified "2023-09-26" @default.
• W2189593721 title "BUSCA DE MARCADORES INFLAMATÓRIOS IL-1β, IL-6 e TNF α EM TRABALHADORES EXPOSTOS A POEIRAS MINERAIS" @default.
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