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- W2189608445 abstract "Objective: The purpose of this study was to determine whether familial non-medullary thyroid cancer (FNMTC) is more aggressive than sporadic thyroid cancer. Subjects and methods: We compared the clinical behavior and outcome of 16 subjects with FNMTC from 7 unrelated kin- dred with those observed in 160 subjects with sporadic PTC (SPTC) from our database. Re- sults: The only different baseline characteristics observed between both groups were: bilateral malignancy, 38% vs. 24%, respectively (p = 0.03), and lymph node metastasis, 56.2% vs. 39%, respectively (p = 0.01). Considering the outcome, in the FNMTC, 9 (56.2%) patients were rende- red free of disease, one patient died from thyroid cancer (6%), and 6/16 (37.5%) had persistent disease. In the SPTC Group, 87 (54%) patients were considered free of disease, 11 (7%) died due to PTC, and 62 (38%) had persistent disease (p = ns). Conclusions: Despite the higher incidence of lymph node metastasis in FNMTC patients this situation seemed not to alter the compared outcome. Arq Bras Endocrinol Metab. 2011;55(3):219-23" @default.
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- W2189608445 date "2011-01-01" @default.
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- W2189608445 title "Patients with familial non-medullary thyroid cancer have an outcome similar to that of patients with sporadic papillary thyroid tumors Pacientes com câncer não medular familiar da tiroide têm evolução similar aos portadores de câncer papilífero esporádico" @default.
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