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- W2189609968 abstract "Summary Although no exact figures are available, it is estimated that more than 100 million laboratory animals are used each year for experimental and other scientific purposes world wide. Even though animal research remains indispensable for progress in medical research, consensus is spreading over the need for replacement, reduction and refinement of animal use, the so-called 3R’s Principle of Russell & Burch. Apart from moral considerations, there are also scientific and economical reasons for the increased interest in 3Rs and these will be discussed. The 3R’s Principle includes a diversity of new methods and research strategies, some of which have become a routine practice in laboratories. A particular interesting approach is now coming from the area of molecular biology. Progress in –omics technologies enable the expression of large numbers of individual genes and proteins to be monitored simultaneously. This makes the technology an interesting tool in drug development and the hazard and safety assessment of chemicals. It is also believed that –omics might have potential to reduce and refine the use of laboratory animals. This paper will review these potentials as well as the obstacles that might limit the implementation of –omics technologies in research and testing." @default.
- W2189609968 created "2016-06-24" @default.
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- W2189609968 date "2006-01-01" @default.
- W2189609968 modified "2023-09-27" @default.
- W2189609968 title "Replacement, Reduction and Refinement in Biomedical Research with Particular Emphasis to the -omics Technologies" @default.
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