Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189635544> ?p ?o ?g. }
- W2189635544 abstract "Abstract High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40,245 controls, we found that the protective allele [G] at one previously-identified CRC polymorphism, rs2736100 near TERT , was associated with EC risk (odds ratio (OR) = 1.08, P = 0.000167); this polymorphism influences the risk of several other cancers. A further CRC polymorphism near TERC also showed evidence of association with EC (OR = 0.92; P = 0.03). Overall, however, there was no good evidence that the set of CRC polymorphisms was associated with EC risk and neither of two previously-reported EC polymorphisms was associated with CRC risk. A combined analysis revealed one genome-wide significant polymorphism, rs3184504, on chromosome 12q24 (OR = 1.10, P = 7.23 × 10 −9 ) with shared effects on CRC and EC risk. This polymorphism, a missense variant in the gene SH2B3 , is also associated with haematological and autoimmune disorders, suggesting that it influences cancer risk through the immune response. Another polymorphism, rs12970291 near gene TSHZ1 , was associated with both CRC and EC (OR = 1.26, P = 4.82 × 10 −8 ), with the alleles showing opposite effects on the risks of the two cancers." @default.
- W2189635544 created "2016-06-24" @default.
- W2189635544 creator A5001140861 @default.
- W2189635544 creator A5002211986 @default.
- W2189635544 creator A5004055647 @default.
- W2189635544 creator A5004264491 @default.
- W2189635544 creator A5004647151 @default.
- W2189635544 creator A5006870605 @default.
- W2189635544 creator A5007009847 @default.
- W2189635544 creator A5007530177 @default.
- W2189635544 creator A5007674739 @default.
- W2189635544 creator A5007768066 @default.
- W2189635544 creator A5009985095 @default.
- W2189635544 creator A5010080336 @default.
- W2189635544 creator A5010716906 @default.
- W2189635544 creator A5010796519 @default.
- W2189635544 creator A5012404195 @default.
- W2189635544 creator A5012742637 @default.
- W2189635544 creator A5014184022 @default.
- W2189635544 creator A5015231590 @default.
- W2189635544 creator A5016100282 @default.
- W2189635544 creator A5016473306 @default.
- W2189635544 creator A5016817677 @default.
- W2189635544 creator A5016908886 @default.
- W2189635544 creator A5017728105 @default.
- W2189635544 creator A5017856517 @default.
- W2189635544 creator A5018777771 @default.
- W2189635544 creator A5018786162 @default.
- W2189635544 creator A5018920539 @default.
- W2189635544 creator A5019063320 @default.
- W2189635544 creator A5019119640 @default.
- W2189635544 creator A5019133187 @default.
- W2189635544 creator A5020564648 @default.
- W2189635544 creator A5020831595 @default.
- W2189635544 creator A5022550644 @default.
- W2189635544 creator A5022577024 @default.
- W2189635544 creator A5023667273 @default.
- W2189635544 creator A5023691407 @default.
- W2189635544 creator A5026326407 @default.
- W2189635544 creator A5027361412 @default.
- W2189635544 creator A5028614473 @default.
- W2189635544 creator A5029739993 @default.
- W2189635544 creator A5030150569 @default.
- W2189635544 creator A5031677626 @default.
- W2189635544 creator A5032104062 @default.
- W2189635544 creator A5032174631 @default.
- W2189635544 creator A5032375890 @default.
- W2189635544 creator A5033702060 @default.
- W2189635544 creator A5034767660 @default.
- W2189635544 creator A5034905453 @default.
- W2189635544 creator A5037104587 @default.
- W2189635544 creator A5037277277 @default.
- W2189635544 creator A5037656386 @default.
- W2189635544 creator A5040540995 @default.
- W2189635544 creator A5040592396 @default.
- W2189635544 creator A5040598662 @default.
- W2189635544 creator A5041111453 @default.
- W2189635544 creator A5042501070 @default.
- W2189635544 creator A5043144062 @default.
- W2189635544 creator A5044421523 @default.
- W2189635544 creator A5044952697 @default.
- W2189635544 creator A5046363977 @default.
- W2189635544 creator A5046502523 @default.
- W2189635544 creator A5046773247 @default.
- W2189635544 creator A5047343715 @default.
- W2189635544 creator A5047790081 @default.
- W2189635544 creator A5047863051 @default.
- W2189635544 creator A5047902635 @default.
- W2189635544 creator A5049055281 @default.
- W2189635544 creator A5049107000 @default.
- W2189635544 creator A5049975246 @default.
- W2189635544 creator A5053177403 @default.
- W2189635544 creator A5053331577 @default.
- W2189635544 creator A5053866155 @default.
- W2189635544 creator A5054360713 @default.
- W2189635544 creator A5059223431 @default.
- W2189635544 creator A5060027800 @default.
- W2189635544 creator A5061298063 @default.
- W2189635544 creator A5062025296 @default.
- W2189635544 creator A5065073451 @default.
- W2189635544 creator A5065075946 @default.
- W2189635544 creator A5066146057 @default.
- W2189635544 creator A5069169073 @default.
- W2189635544 creator A5070568170 @default.
- W2189635544 creator A5074507773 @default.
- W2189635544 creator A5075944195 @default.
- W2189635544 creator A5076119375 @default.
- W2189635544 creator A5076831885 @default.
- W2189635544 creator A5077206620 @default.
- W2189635544 creator A5077296737 @default.
- W2189635544 creator A5077492791 @default.
- W2189635544 creator A5077827698 @default.
- W2189635544 creator A5078353041 @default.
- W2189635544 creator A5078550389 @default.
- W2189635544 creator A5078760536 @default.
- W2189635544 creator A5080840846 @default.
- W2189635544 creator A5081607480 @default.
- W2189635544 creator A5082417116 @default.
- W2189635544 creator A5084496654 @default.
- W2189635544 creator A5086392926 @default.