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- W2189696564 abstract "Introduction: Type 2 diabetes (T2D) is a chronic and multifactorial metabolic disease, which brings great threats to public health. The morbidity of T2D keeps growing, and it is estimated that the population with T2D will rise to 552 million throughout the world by 2030. Effective glycemic control in patients is crucial for the treatment of T2D. However, with progressive deterioration of disease, most patients are usually unable to achieve glycemic targets receiving antidiabetic agent monotherapy. In such cases, combination therapy with different mechanisms of antidiabetic agents is highly desired. In addition, combination therapy can provide advantages beyond better glycemic improvement such as reduced incidence of hypoglycemia and cardiovascular events.Areas covered: We reviewed all the published data regarding the fixed-dose combination therapy of dapagliflozin combined with metformin, including complementary mechanism of action, pharmacodynamics, pharmacokinetics, clinical efficacy and safety.Expert o..." @default.
- W2189696564 created "2016-06-24" @default.
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- W2189696564 date "2015-12-08" @default.
- W2189696564 modified "2023-10-14" @default.
- W2189696564 title "Combination therapy for type 2 diabetes: dapagliflozin plus metformin" @default.
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- W2189696564 doi "https://doi.org/10.1517/14656566.2016.1121235" @default.
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