Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189729259> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2189729259 abstract "circumvent extensive first-pass metabolism and avoid degradation in the gastrointestinal tract by enzymes and bacteria. This system serves as the better solution for the administration of drugs having low bioavailability like idebenone. Idebenone is synthetic analogue of coenzyme Q10 (CoQ10), a vital cell membrane antioxidant administered in friedreich's ataxia, duchenne muscular dystrophy, becker muscular dystrophy, alzheimer's disease, leber's hereditary optic neuropathy, MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis with stroke-like episodes), parkinson's disease mitochondrial myopathies etc.. The drug is practically water insoluble and shows limited bioavailability after oral administration due to a significant degree of first pass metabolism (99%). The low bioavailability of drug demands frequent dosing, hence the aim of the study was to demonstrate in vitro enhancement of drug penetration using Keshary – Chien diffusion cell. For demonstration varying concentrations of penetration enhancers and drug were prepared. Different penetration enhancers used were sodium lauryl sulphate, disodium ethylene diamine tetraacetic acid, urea, sorbitol, oleic acid, dimethylsulphoxide, physical mixtures with beta cyclodextrin, hydroxypropyl beta cyclodextrin, and complex of drug with hydroxypropyl beta cyclodextrin through buccal drug delivery system and tested for highest penetration. Drug complex with hydroxyl propyl cyclodextrin showed maximum enhancement ratio of 45.93 when compared with the enhancement ratio of other penetration enhances which ranged from 1.08 to 13.52. Hence, when compared with different penetration enhancers, this inclusion complex of idebenone with HPsCD can itself act as a best penetration enhancer for buccal drug delivery of idebenone. Overall, we can say that Idebenone Inclusion complex with HPsCD is the best way of enhancing the permeation of drug through buccal mucosa." @default.
- W2189729259 created "2016-06-24" @default.
- W2189729259 creator A5011491663 @default.
- W2189729259 creator A5027399139 @default.
- W2189729259 creator A5057372491 @default.
- W2189729259 creator A5070239973 @default.
- W2189729259 creator A5086752540 @default.
- W2189729259 date "2011-01-01" @default.
- W2189729259 modified "2023-09-27" @default.
- W2189729259 title "Effect of Permeation Enhancers on Permeation Kinetics of Idebenone through the Bovine Buccal Mucosa" @default.
- W2189729259 cites W1975863776 @default.
- W2189729259 cites W1994858883 @default.
- W2189729259 cites W1999231173 @default.
- W2189729259 cites W2016654910 @default.
- W2189729259 cites W2029438930 @default.
- W2189729259 cites W2045456307 @default.
- W2189729259 cites W2071286665 @default.
- W2189729259 cites W2075368687 @default.
- W2189729259 cites W2081699252 @default.
- W2189729259 cites W2331626304 @default.
- W2189729259 hasPublicationYear "2011" @default.
- W2189729259 type Work @default.
- W2189729259 sameAs 2189729259 @default.
- W2189729259 citedByCount "1" @default.
- W2189729259 crossrefType "journal-article" @default.
- W2189729259 hasAuthorship W2189729259A5011491663 @default.
- W2189729259 hasAuthorship W2189729259A5027399139 @default.
- W2189729259 hasAuthorship W2189729259A5057372491 @default.
- W2189729259 hasAuthorship W2189729259A5070239973 @default.
- W2189729259 hasAuthorship W2189729259A5086752540 @default.
- W2189729259 hasConcept C181389837 @default.
- W2189729259 hasConcept C185592680 @default.
- W2189729259 hasConcept C195735259 @default.
- W2189729259 hasConcept C2777403772 @default.
- W2189729259 hasConcept C2780035454 @default.
- W2189729259 hasConcept C55493867 @default.
- W2189729259 hasConcept C71924100 @default.
- W2189729259 hasConcept C98274493 @default.
- W2189729259 hasConceptScore W2189729259C181389837 @default.
- W2189729259 hasConceptScore W2189729259C185592680 @default.
- W2189729259 hasConceptScore W2189729259C195735259 @default.
- W2189729259 hasConceptScore W2189729259C2777403772 @default.
- W2189729259 hasConceptScore W2189729259C2780035454 @default.
- W2189729259 hasConceptScore W2189729259C55493867 @default.
- W2189729259 hasConceptScore W2189729259C71924100 @default.
- W2189729259 hasConceptScore W2189729259C98274493 @default.
- W2189729259 hasIssue "4" @default.
- W2189729259 hasLocation W21897292591 @default.
- W2189729259 hasOpenAccess W2189729259 @default.
- W2189729259 hasPrimaryLocation W21897292591 @default.
- W2189729259 hasRelatedWork W1540223790 @default.
- W2189729259 hasRelatedWork W182379229 @default.
- W2189729259 hasRelatedWork W1893400159 @default.
- W2189729259 hasRelatedWork W1979338265 @default.
- W2189729259 hasRelatedWork W2013802847 @default.
- W2189729259 hasRelatedWork W2014034100 @default.
- W2189729259 hasRelatedWork W2035053846 @default.
- W2189729259 hasRelatedWork W2113862110 @default.
- W2189729259 hasRelatedWork W2262204096 @default.
- W2189729259 hasRelatedWork W2333908305 @default.
- W2189729259 hasRelatedWork W2416676996 @default.
- W2189729259 hasRelatedWork W2571239811 @default.
- W2189729259 hasRelatedWork W2738573829 @default.
- W2189729259 hasRelatedWork W2992517957 @default.
- W2189729259 hasRelatedWork W2997990408 @default.
- W2189729259 hasRelatedWork W3136721263 @default.
- W2189729259 hasRelatedWork W3197093877 @default.
- W2189729259 hasRelatedWork W2189388387 @default.
- W2189729259 hasRelatedWork W2464609671 @default.
- W2189729259 hasRelatedWork W2509139524 @default.
- W2189729259 hasVolume "45" @default.
- W2189729259 isParatext "false" @default.
- W2189729259 isRetracted "false" @default.
- W2189729259 magId "2189729259" @default.
- W2189729259 workType "article" @default.