Matches in SemOpenAlex for { <https://semopenalex.org/work/W2189788457> ?p ?o ?g. }
- W2189788457 abstract "Differentiation of cellular lineages is facilitated by asymmetric segregation of fate determinants between dividing cells. In budding yeast, various aging factors segregate to the aging (mother)-lineage, with poorly understood consequences. In this study, we show that yeast mother cells form a protein aggregate during early replicative aging that is maintained as a single, asymmetrically inherited deposit over the remaining lifespan. Surprisingly, deposit formation was not associated with stress or general decline in proteostasis. Rather, the deposit-containing cells displayed enhanced degradation of cytosolic proteasome substrates and unimpaired clearance of stress-induced protein aggregates. Deposit formation was dependent on Hsp42, which collected non-random client proteins of the Hsp104/Hsp70-refolding machinery, including the prion Sup35. Importantly, loss of Hsp42 resulted in symmetric inheritance of its constituents and prolonged the lifespan of the mother cell. Together, these data suggest that protein aggregation is an early aging-associated differentiation event in yeast, having a two-faceted role in organismal fitness." @default.
- W2189788457 created "2016-06-24" @default.
- W2189788457 creator A5002109405 @default.
- W2189788457 creator A5026135455 @default.
- W2189788457 date "2015-11-06" @default.
- W2189788457 modified "2023-09-30" @default.
- W2189788457 title "Protein aggregates are associated with replicative aging without compromising protein quality control" @default.
- W2189788457 cites W1568630971 @default.
- W2189788457 cites W1894813487 @default.
- W2189788457 cites W1939575473 @default.
- W2189788457 cites W1962225963 @default.
- W2189788457 cites W1963578989 @default.
- W2189788457 cites W1965813899 @default.
- W2189788457 cites W1967025628 @default.
- W2189788457 cites W1969615465 @default.
- W2189788457 cites W1969634682 @default.
- W2189788457 cites W1971108880 @default.
- W2189788457 cites W1973205231 @default.
- W2189788457 cites W1975396085 @default.
- W2189788457 cites W1975712445 @default.
- W2189788457 cites W1980031483 @default.
- W2189788457 cites W1980431043 @default.
- W2189788457 cites W1981681091 @default.
- W2189788457 cites W1981840094 @default.
- W2189788457 cites W1986339417 @default.
- W2189788457 cites W1987327305 @default.
- W2189788457 cites W1989172027 @default.
- W2189788457 cites W1997982747 @default.
- W2189788457 cites W2008217034 @default.
- W2189788457 cites W2013429682 @default.
- W2189788457 cites W2013830587 @default.
- W2189788457 cites W2017529721 @default.
- W2189788457 cites W2020677693 @default.
- W2189788457 cites W2028728539 @default.
- W2189788457 cites W2036404841 @default.
- W2189788457 cites W2036735052 @default.
- W2189788457 cites W2045929752 @default.
- W2189788457 cites W2046445620 @default.
- W2189788457 cites W2047936551 @default.
- W2189788457 cites W2054791517 @default.
- W2189788457 cites W2058236814 @default.
- W2189788457 cites W2058462185 @default.
- W2189788457 cites W2059277971 @default.
- W2189788457 cites W2061976315 @default.
- W2189788457 cites W2073363233 @default.
- W2189788457 cites W2074467340 @default.
- W2189788457 cites W2074577396 @default.
- W2189788457 cites W2080661989 @default.
- W2189788457 cites W2082382374 @default.
- W2189788457 cites W2089897141 @default.
- W2189788457 cites W2092587339 @default.
- W2189788457 cites W2092986760 @default.
- W2189788457 cites W2094371012 @default.
- W2189788457 cites W2101027541 @default.
- W2189788457 cites W2105375182 @default.
- W2189788457 cites W2109350663 @default.
- W2189788457 cites W2112660386 @default.
- W2189788457 cites W2114123456 @default.
- W2189788457 cites W2115446988 @default.
- W2189788457 cites W2119106496 @default.
- W2189788457 cites W2121020843 @default.
- W2189788457 cites W2123844682 @default.
- W2189788457 cites W2124466665 @default.
- W2189788457 cites W2125713094 @default.
- W2189788457 cites W2126525177 @default.
- W2189788457 cites W2132744522 @default.
- W2189788457 cites W2135532366 @default.
- W2189788457 cites W2135636602 @default.
- W2189788457 cites W2135887469 @default.
- W2189788457 cites W2136201006 @default.
- W2189788457 cites W2136758030 @default.
- W2189788457 cites W2139066576 @default.
- W2189788457 cites W2139947061 @default.
- W2189788457 cites W2140197221 @default.
- W2189788457 cites W2143966405 @default.
- W2189788457 cites W2146721676 @default.
- W2189788457 cites W2146865209 @default.
- W2189788457 cites W2148505202 @default.
- W2189788457 cites W2151325719 @default.
- W2189788457 cites W2154164675 @default.
- W2189788457 cites W2157649587 @default.
- W2189788457 cites W2162930176 @default.
- W2189788457 cites W2169060533 @default.
- W2189788457 doi "https://doi.org/10.7554/elife.06197" @default.
- W2189788457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4635334" @default.
- W2189788457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26544680" @default.
- W2189788457 hasPublicationYear "2015" @default.
- W2189788457 type Work @default.
- W2189788457 sameAs 2189788457 @default.
- W2189788457 citedByCount "110" @default.
- W2189788457 countsByYear W21897884572016 @default.
- W2189788457 countsByYear W21897884572017 @default.
- W2189788457 countsByYear W21897884572018 @default.
- W2189788457 countsByYear W21897884572019 @default.
- W2189788457 countsByYear W21897884572020 @default.
- W2189788457 countsByYear W21897884572021 @default.
- W2189788457 countsByYear W21897884572022 @default.
- W2189788457 countsByYear W21897884572023 @default.
- W2189788457 crossrefType "journal-article" @default.
- W2189788457 hasAuthorship W2189788457A5002109405 @default.