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• W2189905693 abstract "Future Medicinal ChemistryVol. 7, No. 17 CommentaryTargeting chemokine receptors for HIV: past, present and futureSimon P FrickerSimon P Fricker*Author for correspondence: E-mail Address: simonpfricker@gmail.com Biopharma, 13 Glenwood Lane, North Grafton, MA 01536, USASearch for more papers by this authorPublished Online:2 Dec 2015https://doi.org/10.4155/fmc.15.153AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: CCR5chemokine receptorCXCR4HIVmaravirocplerixaforReferences1 Berger EA. Finding fusin/CXCR4, the first '2nd receptor' for HIV entry. Front. Immunol. 6, 283 (2015).Crossref, Medline, Google Scholar2 De Clercq E. The bicyclam AMD3100 story. Nat. Rev. Drug Discov. 2(7), 581–587 (2003).Crossref, Medline, CAS, Google Scholar3 Wilkin TJ, Gulick RM. CCR5 antagonism in HIV infection: current concepts and future opportunities. Annu. Rev. Med. 63, 81–93 (2012).Crossref, Medline, CAS, Google Scholar4 Didigu CA, Doms RW. Novel approaches to inhibit HIV entry. Viruses 4(2), 309–324 (2012).Crossref, Medline, CAS, Google Scholar5 Fricker SP, Metz M. Chemokine receptor modeling: an interdisciplinary approach to drug design. Future Med. Chem. 6(1), 91–114 (2014).Link, CAS, Google Scholar6 Van Der Ryst E. Maraviroc – A CCR5 antagonist for the treatment of HIV-1 infection. Front. Immunol. 6, 277 (2015).Crossref, Medline, Google Scholar7 Parra J, Portilla J, Pulido F et al. Clinical utility of maraviroc. Clin. Drug Investig. 31(8), 527–542 (2011).Crossref, Medline, CAS, Google Scholar8 Llibre JM, Rivero A, Rojas JF et al. Safety, efficacy and indications of prescription of maraviroc in clinical practice: factors associated with clinical outcomes. Antiviral Res. 120, 79–84 (2015).Crossref, Medline, CAS, Google Scholar9 Gerlach LO, Skerlj RT, Bridger GJ, Schwartz TW. Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. J. Biol. Chem. 276(17), 14153–14160 (2001).Crossref, Medline, CAS, Google Scholar10 Skerlj RT, Bridger GJ, Kaller A et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J. Med. Chem. 53(8), 3376–3388 (2010).Crossref, Medline, CAS, Google Scholar11 Moyle G, Dejesus E, Boffito M et al. Proof of activity with AMD11070, an orally bioavailable inhibitor of CXCR4-tropic HIV type 1. Clin. Infect. Dis. 48(6), 798–805 (2009).Crossref, Medline, CAS, Google Scholar12 Pusic I, Dipersio JF. Update on clinical experience with AMD3100, an SDF-1/CXCL12-CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells. Curr. Opin. Hematol. 17(4), 319–326 (2010).Crossref, Medline, CAS, Google Scholar13 Vicenzi E, Liò P, Poli G. The puzzling role of CXCR4 in human immunodeficiency virus infection. Theranostics 3(1), 18–25 (2013).Crossref, Medline, CAS, Google Scholar14 Wilen CB, Tilton JC, Doms RW. HIV: cell binding and entry. Cold Spring Harb. Perspect. Med. 2(8), pii: a006866 (2012).Crossref, Google Scholar15 Passaes CP, Sáez-Cirión A. HIV cure research: advances and prospects. Virology 454–455, 340–352 (2014).Crossref, Medline, CAS, Google Scholar16 Sierra-Enguita R, Rodriguez C, Aguilera A et al. X4 tropic viruses are on the rise in recent HIV-1 seroconverters in Spain. AIDS 28(11), 1603–1609 (2014).Crossref, Medline, CAS, Google Scholar17 Teicher BA, Fricker SP. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin. Cancer. Res. 16(11), 2927–2931 (2010).Crossref, Medline, CAS, Google Scholar18 Zhao H, Prosser AR, Liotta DC, Wilson LJ. Discovery of novel N-aryl piperazine CXCR4 antagonists. Bioorg. Med. Chem. Lett. doi:10.1016/j.bmcl.2015.04.036 (2015) (Epub ahead of print).Google Scholar19 Allers K, Schneider T. CCR5Δ32 mutation and HIV infection: basis for curative HIV therapy. Curr. Opin. Virol. 14, 24–29 (2015).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 7, No. 17 STAY CONNECTED Metrics Downloaded 67 times History Published online 2 December 2015 Published in print November 2015 Information© Future Science LtdKeywordsCCR5chemokine receptorCXCR4HIVmaravirocplerixaforFinancial & competing interests disclosureThe author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download" @default.
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