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- W2189915517 abstract "In an effort to rapidly access vancomycin analogues bearing diverse functionality at the 6c-Cl (the ‘in-chloride’) position, a two-step dechlorination/cross-coupling protocol was developed. Conditions for efficient cross-coupling of the relatively unreactive 6c-Cl group were found that ensure high conversion with minimal product decomposition. A set of 2c-dechloro-6c-functionalized vancomycin derivatives was prepared, and antibiotic activities of the compounds were evaluated against a panel of vancomycin-resistant and vancomycin-susceptible strains. Results from biological testing further underscore the steric sensitivity of vancomycin’s binding pocket." @default.
- W2189915517 created "2016-06-24" @default.
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- W2189915517 date "2016-02-01" @default.
- W2189915517 modified "2023-10-14" @default.
- W2189915517 title "A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin ‘in-chloride’" @default.
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- W2189915517 doi "https://doi.org/10.1016/j.bmcl.2015.12.027" @default.
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