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- W2189965588 abstract "Viruses may be involved in the pathogenesis of Type 1 Diabetes Mellitus (T1DM), either through direct β-cell infection or as triggers of autoimmunity. To evaluate the T-cell proliferation in response to Enterovirus antigens including Coxsackievirus B and Poliovirus in addition to Adenovirus in children with T1DM, and screening for specific anti-viral IgG antibodies. In 60 Iraqi children with recent onset of T1DM, Lymphocyte proliferation was analyzed using MTT assay by culturing Peripheral Blood Lymphocytes (PBLs) with Coxsackie Virus B5 (CVB5), Adenovirus, and Polio vaccine. Serum IgG against these viruses were detected quantitatively with an indirect ELISA. No significant differences were shown in the PBL proliferative percentage in response to Con-A mitogen and tested viruses (CVB5 and Adenovirus) between T1DM and healthy controls, but it showed a significant decline in patients in response to Polio vaccine. High significant mean proliferative percentage for all tested viruses were detected in those patients who were sero-positive for anti- viral IgG as compared to the sero-negative IgG diabetic children. In children with new- onset diabetes, mean proliferative percentage of PBL was generally decreased, but higher in children who were sero positive to anti- viral IgG antibodies." @default.
- W2189965588 created "2016-06-24" @default.
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- W2189965588 date "2010-05-31" @default.
- W2189965588 modified "2023-09-28" @default.
- W2189965588 title "An Association of T- cell proliferation and anti- Coxsackie Virus B5, anti-Polio, and anti-Adeno IgG antibodies in T1DM Children" @default.
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