Matches in SemOpenAlex for { <https://semopenalex.org/work/W2190078377> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2190078377 endingPage "H2106" @default.
- W2190078377 startingPage "H2095" @default.
- W2190078377 abstract "Oxidative stress may alter cardiac function by affecting intracellular free Zn2+ concentrations ([Zn2+]i). Rabbit ventricular myocytes loaded with fura 2 were used to fluorometrically measure resting [Zn2+]i (0.23 +/- 0.03 nM) and intracellular Ca2+ concentration ([Ca2+]i) (36 +/- 7 nM). Fluorescence quenching by the heavy metal chelator N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine was used to quantitate [Zn2+]i. The thiol-reactive oxidants hypochlorous acid (0.1 mM) and selenite (1 mM) increased [Zn2+]i to 7.7 +/- 1.7 and 6.1 +/- 1.7 nM, respectively, within 5 min. Dithiothreitol (0.5 mM), a disulfide-reducing agent, rapidly restored normal [Zn2+]i. The oxidants did not affect [Ca2+]i. However, depolarization-induced Ca2+ transients and Ca2+ currents were zinc dependent. [Zn2+]i-associated fluorescence was substantial and, if ignored, it led to overestimation of [Ca2+]i by approximately twofold before oxidant treatment and by approximately eightfold after oxidants. The results demonstrate that [Zn2+]i 1) can be greatly increased by thiol-reactive oxidants; 2) may contribute to oxidant-induced alterations of excitation-contraction coupling; and 3) has strong fura 2 fluorescence which, if overlooked, can lead to significant overestimation of [Ca2+]i." @default.
- W2190078377 created "2016-06-24" @default.
- W2190078377 creator A5019062339 @default.
- W2190078377 creator A5039691331 @default.
- W2190078377 creator A5067979833 @default.
- W2190078377 date "1997-05-01" @default.
- W2190078377 modified "2023-10-18" @default.
- W2190078377 title "Oxidants increase intracellular free Zn2+ concentration in rabbit ventricular myocytes" @default.
- W2190078377 doi "https://doi.org/10.1152/ajpheart.1997.272.5.h2095" @default.
- W2190078377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9176274" @default.
- W2190078377 hasPublicationYear "1997" @default.
- W2190078377 type Work @default.
- W2190078377 sameAs 2190078377 @default.
- W2190078377 citedByCount "34" @default.
- W2190078377 countsByYear W21900783772012 @default.
- W2190078377 countsByYear W21900783772013 @default.
- W2190078377 countsByYear W21900783772015 @default.
- W2190078377 countsByYear W21900783772017 @default.
- W2190078377 countsByYear W21900783772019 @default.
- W2190078377 countsByYear W21900783772020 @default.
- W2190078377 countsByYear W21900783772021 @default.
- W2190078377 countsByYear W21900783772022 @default.
- W2190078377 countsByYear W21900783772023 @default.
- W2190078377 crossrefType "journal-article" @default.
- W2190078377 hasAuthorship W2190078377A5019062339 @default.
- W2190078377 hasAuthorship W2190078377A5039691331 @default.
- W2190078377 hasAuthorship W2190078377A5067979833 @default.
- W2190078377 hasConcept C121332964 @default.
- W2190078377 hasConcept C121745418 @default.
- W2190078377 hasConcept C12554922 @default.
- W2190078377 hasConcept C134018914 @default.
- W2190078377 hasConcept C181199279 @default.
- W2190078377 hasConcept C185592680 @default.
- W2190078377 hasConcept C207200792 @default.
- W2190078377 hasConcept C2777824588 @default.
- W2190078377 hasConcept C2780908991 @default.
- W2190078377 hasConcept C2781324293 @default.
- W2190078377 hasConcept C4141045 @default.
- W2190078377 hasConcept C55493867 @default.
- W2190078377 hasConcept C62520636 @default.
- W2190078377 hasConcept C79879829 @default.
- W2190078377 hasConcept C86803240 @default.
- W2190078377 hasConcept C91881484 @default.
- W2190078377 hasConceptScore W2190078377C121332964 @default.
- W2190078377 hasConceptScore W2190078377C121745418 @default.
- W2190078377 hasConceptScore W2190078377C12554922 @default.
- W2190078377 hasConceptScore W2190078377C134018914 @default.
- W2190078377 hasConceptScore W2190078377C181199279 @default.
- W2190078377 hasConceptScore W2190078377C185592680 @default.
- W2190078377 hasConceptScore W2190078377C207200792 @default.
- W2190078377 hasConceptScore W2190078377C2777824588 @default.
- W2190078377 hasConceptScore W2190078377C2780908991 @default.
- W2190078377 hasConceptScore W2190078377C2781324293 @default.
- W2190078377 hasConceptScore W2190078377C4141045 @default.
- W2190078377 hasConceptScore W2190078377C55493867 @default.
- W2190078377 hasConceptScore W2190078377C62520636 @default.
- W2190078377 hasConceptScore W2190078377C79879829 @default.
- W2190078377 hasConceptScore W2190078377C86803240 @default.
- W2190078377 hasConceptScore W2190078377C91881484 @default.
- W2190078377 hasIssue "5" @default.
- W2190078377 hasLocation W21900783771 @default.
- W2190078377 hasLocation W21900783772 @default.
- W2190078377 hasOpenAccess W2190078377 @default.
- W2190078377 hasPrimaryLocation W21900783771 @default.
- W2190078377 hasRelatedWork W1899233195 @default.
- W2190078377 hasRelatedWork W1973887578 @default.
- W2190078377 hasRelatedWork W2020712168 @default.
- W2190078377 hasRelatedWork W2069123268 @default.
- W2190078377 hasRelatedWork W2092389024 @default.
- W2190078377 hasRelatedWork W2190078377 @default.
- W2190078377 hasRelatedWork W2279528449 @default.
- W2190078377 hasRelatedWork W2339794357 @default.
- W2190078377 hasRelatedWork W3150026354 @default.
- W2190078377 hasRelatedWork W3151887034 @default.
- W2190078377 hasVolume "272" @default.
- W2190078377 isParatext "false" @default.
- W2190078377 isRetracted "false" @default.
- W2190078377 magId "2190078377" @default.
- W2190078377 workType "article" @default.