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• W2190162356 abstract "A cDNA, recently cloned (by Krieg et al. (1998)) from mouse skin, was shown to encode a 12(R)-lipoxygenase. When expressed in HEK cells, the recombinant protein converted methyl arachidonate into the corresponding 12-HETE ester which was shown to be the R-enantiomer by chiral phase chromatography. Neither arachidonic acid nor linoleic acid were substrates for the recombinant protein. The structure of the 12(R)-lipoxygenase gene is unique among all animal lipoxygenases in that it is divided into 15 exons and 14 introns spanning approximately 12.5 kb. By interspecific backcross analysis, the 12(R)-lipoxygenase gene was localized to the central region of mouse chromosome 11." @default.
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• W2190162356 date "1999-03-05" @default.
• W2190162356 modified "2023-09-26" @default.
• W2190162356 title "Murine 12(<i>R</i>)-lipoxygenase: functional expression, genomic structure and chromosomal localization¹" @default.
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• W2190162356 doi "https://doi.org/10.1016/s0014-5793(99)00196-9" @default.
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